A comparison in association and linkage genome-wide scans for alcoholism susceptibility genes using single-nucleotide polymorphisms
A comparison in association and linkage genome-wide scans for alcoholism susceptibility genes using single-nucleotide polymorphisms
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DOI：
10.1186/1471-2156-6-s1-s89
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发表时间：
2005-12-30
期刊：
影响因子：
2.9
通讯作者：
Tsai, YY
中科院分区：
文献类型：
--
作者：
Chiu, YF;Liu, SY;Tsai, YY
我们使用微卫星和单核苷酸多态性 (SNP) 标记进行全基因组连锁扫描。确定了与酗酒易感基因相关的最有力证据的区域。使用滑动窗口方法对这些区域的 SNP 进行单倍型分析。此外，我们使用 SNP 数据进行了全基因组关联扫描。这些区域中的 SNP 有相关证据（P
We conducted genome-wide linkage scans using both microsatellite and single-nucleotide polymorphism ( SNP) markers. Regions showing the strongest evidence of linkage to alcoholism susceptibility genes were identified. Haplotype analyses using a sliding-window approach for SNPs in these regions were performed. In addition, we performed a genome-wide association scan using SNP data. SNPs in these regions with evidence of association ( P