Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands.
Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands.
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荷兰发生多起与戊型肝炎病毒感染相关的急性肝炎病例。
DOI：
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发表时间：
2003
影响因子：
11.8
通讯作者：
M. Koopmans
中科院分区：
文献类型：
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作者：
Marc;W. M. Jaspers;W. V. D. van der Poel;F. Verschoor;A. M. de Roda Husman;H. Winter;H. Zaaijer;M. Koopmans
越来越多的证据表明，戊型肝炎病毒（HEV）感染可能发生在发达国家，猪可能作为一个水库。我们报告了一组2例确诊病例和1例疑似戊型肝炎相关病例。1例病例的分型毒株与北美和欧洲发现的HEV毒株有关，也与荷兰发现的一群猪HEV毒株有关。我们的研究结果表明，工业化国家本地获得的戊型肝炎病毒感染可能会被忽视。在荷兰急性肝炎患者中，在诊断为自身免疫性肝炎并开始类固醇治疗之前，应考虑常规检测HEV感染。
Increasing evidence suggests that hepatitis E virus (HEV) infection may occur in developed countries and that swine may act as a reservoir. We report a cluster of 2 confirmed cases and 1 presumptive case of hepatitis associated with HEV. The typed strain from 1 case was related to HEV strains found in North America and Europe, and it was also related to a cluster of swine HEV strains found in The Netherlands. Our findings indicate that locally acquired HEV infections in industrialized countries may be overlooked. Routine testing for HEV infection in patients with acute hepatitis in The Netherlands should be considered before a diagnosis of autoimmune hepatitis is reached and steroid therapy is initiated.