E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro
E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro
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DOI：
10.1006/bbrc.2000.2292
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发表时间：
2000-03-16
影响因子：
3.1
通讯作者：
Frame, MC
中科院分区：
文献类型：
--
作者：
Owens, DW;Brunton, VG;Frame, MC
角质形成细胞分化信号的起源仍然未知。在这里，我们表明，钙离子和密度诱导的E-钙粘蛋白，但不是P-钙粘蛋白的易位，伴随着诱导分化特异性蛋白在培养的角质形成细胞。抗体，人工集群细胞表面E-钙粘蛋白在低细胞外Ca 2+也诱导分化特异性蛋白，牵连E-钙粘蛋白作为角质形成细胞分化的决定因素在体外。(C)北京大学出版社.
The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca2+- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca2+ also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro. (C) 2000 Academic Press.