Preparation and Properties of Brij97-Based Curcumin-Encapsulated O/W Microemulsions
Preparation and Properties of Brij97-Based Curcumin-Encapsulated O/W Microemulsions
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DOI：
10.4028/www.scientific.net/amr.924.10
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发表时间：
2014-04
期刊：
影响因子：
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通讯作者：
Zhong Wang;F. Guo;J. Lu;Lingcha Wei;Xin Liu;Wu Zhou
中科院分区：
文献类型：
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作者：
Zhong Wang;F. Guo;J. Lu;Lingcha Wei;Xin Liu;Wu Zhou
氧化损伤是现代世界的一个公共卫生问题，促进饮食抗氧化剂，如姜黄素，是一个有前途的策略。然而，姜黄素不稳定，水溶性差，生物利用度差。本研究采用药学上可接受的Brij 97非离子表面活性剂构建了一种新型的姜黄素O/W型微乳，并对微乳中姜黄素的性质进行了评价。测定了Brij 97/异丙醇/乙酸乙酯/水体系的拟三元相图，并根据逾渗理论，通过电导率测定确定了微乳液的三个微区：W/O、双连续和O/Ware。对一系列载姜黄素的O/W型微乳的性质研究表明：（1）姜黄素在此条件下的缓释符合一级动力学规律：（2）姜黄素在一定时间范围内对阳光的稳定性较好;（3）姜黄素具有较强的抗氧化活性，清除超氧自由基的IC_（50）在31.5 ~ 17.2 μg/ml之间。此外，同系物乙酸酯的结构差异似乎没有影响姜黄素的稳定性和释放行为，而研究的性质显然取决于微乳液中的ME/乙酸酯比例。本研究为姜黄素的保护作用和传递机制的研究提供了理论依据。
Oxidative damage is a public health issue in the modern world and promoting dietary anti-oxidants, such as curcumin, is a promising strategy. However, curcumin is unstable and poorly water-soluble and of poor bioavailability. This study constructed new curcumin-loaded O/W microemulsions using a pharmaceutically accepted Brij97 nonionic surfactant and evaluated several properties of curcumin encapsulated in the microemulsions. The pseudo-ternary phase diagram of Brij97/isopropyl alcohol/ethyl acetate/water system was determined and three microregions of the microemulsionsW/O, bicontinuous, and O/Ware identified by conductivity measurements, according to percolation theory. The properties investigation of a series of curcumin-loaded O/W microemulsions indicates: (1) The curcumin in such a situation performs sustained release following the first-order kinetics; (2) Better stability of curcumin to the sun light is observed over a time scale; (3) The curcumin presents relatively high anti-oxidant activity, with the IC50 in between 31.5 and 17.2 μg/ml on scavenging the superoxide radicals. In addition, the structure difference in the homologues acetate seems having no effect on the stability and release behavior of curcumin, while the investigated properties clearly depend on the ME/acetate ratio in the microemulsions. This study might be a potential help to the protection and the delivery of curcumin.