Tissue and blood T-lymphocyte subpopulations in erythema nodosum leprosum.
Tissue and blood T-lymphocyte subpopulations in erythema nodosum leprosum.
复制标题
麻风结节性红斑的组织和血液 T 淋巴细胞亚群。
作者：
R. Modlin;A. Bakke;S. Vaccaro;D. Horwitz;C. Taylor;T. Rea
为研究麻风结节性红斑（ENL）患者的T淋巴细胞，应用单克隆抗体对ENL患者和非反应性瘤型麻风患者血液和皮损中的T淋巴细胞亚群进行了鉴定。与对照组相比，非反应性麻风瘤患者的血液中淋巴细胞减少，泛T细胞、辅助诱导细胞和抑制细胞毒亚群比例减少，但辅助抑制细胞比例正常。ENL患者与对照组无显著差异。在皮肤病变中，发现泡沫组织细胞中存在辅助和抑制表型的混合物，与无反应的麻风瘤组织相比，ENL组织中辅助诱导表型的细胞较多，抑制细胞毒性表型的细胞较少。在22例同时检查组织和血液T细胞亚群的患者中，组织和血液辅助-抑制细胞比率之间没有相关性，表明某种选择过程将淋巴细胞从外周血带入组织。
To study T lymphocytes in erythema nodosum leprosum (ENL), monoclonal antibodies were used to identify T-lymphocyte subpopulations in the blood and skin lesions of patients with ENL and patients with nonreactional lepromatous leprosy. The blood of nonreactional lepromatous patients had a lymphopenia and a proportionate reduction in pan T cells, helper-inducer, and suppressor-cytotoxic subsets, but a normal helper-suppressor ratio, as compared with controls. Patients with ENL did not differ significantly from the controls. In skin lesions, an admixture of helper and suppressor phenotypes among foamy histiocytes was found. The ENL tissue had more numerous cells of the helper-inducer phenotype and fewer of the suppressor-cytotoxic phenotype, as compared with nonreaction lepromatous tissues. In 22 patients with simultaneous examination of tissue and blood T-cell subsets, there was no correlation between tissue and blood helper-suppressor ratios, indicating that some sort of selection process brings lymphocytes into tissues from peripheral blood.