Development of an Instrument for Measurement of Light Scattering at the Corneal Epithelial Basement Membrane in Diabetic Patients
Development of an Instrument for Measurement of Light Scattering at the Corneal Epithelial Basement Membrane in Diabetic Patients
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DOI：
10.1007/s10384-007-0427-4
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发表时间：
2007-06
影响因子：
2.4
通讯作者：
N. Takahashi;M. Wakuta;N. Morishige;T. Chikama;T. Nishida;Yasuhiro Sumii
中科院分区：
文献类型：
--
作者：
N. Takahashi;M. Wakuta;N. Morishige;T. Chikama;T. Nishida;Yasuhiro Sumii
目的糖尿病并发症与基底膜异常有关。我们已经开发出一种光散射检测系统（LSDS），专门用于测量角膜上皮基底膜的光散射，并确定了由LSDS在糖尿病patients.MethodsThirty非糖尿病对照组和40名糖尿病受试者参加了这项研究的结果的重现性和临床意义。在角膜上皮基底膜的光散射测量与LSDS.ResultsThe测量的光散射在角膜基底膜被认为是可重复的。对照组的LSDS指数（平均值± SD）为28.1 ± 4.8，轻度糖尿病视网膜病变受试者为35.7 ± 6.3，重度糖尿病视网膜病变受试者为42.7 ± 8.6。这表明，在角膜基底膜的LSDS指数是成比例的糖尿病retinopathy.ConclusionsMeasurement的程度在角膜上皮基底膜的光散射是可能的LSDS，是相对容易执行，是可重复的。LSDS可能被证明适用于糖尿病眼部并发症的早期检测。Jpn J Ophthalmol 2007;51：185-190 ©日本眼科学会2007
PurposeDiabetic complications are associated with abnormality of the basement membranes. We have developed a light-scattering detection system (LSDS) specifically for measurement of light scattering at the corneal epithelial basement membrane, and have determined the reproducibility and clinical significance of the results obtained by the LSDS in diabetic patients.MethodsThirty nondiabetic controls and 40 diabetic subjects participated in the study. Light scattering at the corneal epithelial basement membrane was measured with the LSDS.ResultsThe measurement of light scattering at the corneal basement membrane was found to be reproducible. The LSDS index (mean ± SD) was 28.1 ± 4.8 in controls, 35.7 ± 6.3 in mild diabetic retinopathy subjects, and 42.7 ± 8.6 in severe diabetic retinopathy subjects. This demonstrated that the LSDS index at the corneal basement membrane is proportional to the extent of diabetic retinopathy.ConclusionsMeasurement of light scattering at the corneal epithelial basement membrane is possible with the LSDS, is relatively easy to perform, and is reproducible. The LSDS may prove suitable for the early detection of diabetic ocular complications.Jpn J Ophthalmol2007;51:185–190 © Japanese Ophthalmological Society 2007