The lifetime and past-year prevalence of dual diagnosis in people with schizophrenia across Europe: findings from the European Schizophrenia Cohort (EuroSC)
The lifetime and past-year prevalence of dual diagnosis in people with schizophrenia across Europe: findings from the European Schizophrenia Cohort (EuroSC)
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DOI：
10.1007/s00406-012-0305-z
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发表时间：
2012-10-01
影响因子：
4.7
通讯作者：
Toumi, Mondher
中科院分区：
文献类型：
--
作者：
Carra, Giuseppe;Johnson, Sonia;Toumi, Mondher
在美国以外的国家，人们对精神分裂症患者的药物和酒精共病率知之甚少。大多数研究从单个国家招募。新获得的数据提供了一个无与伦比的机会，以调查在法国，德国和英国的精神分裂症患者同时对酒精和其他精神活性物质的共病依赖的患病率。欧洲精神分裂症队列研究数据集使用半结构化临床访谈来建立DSM-IV诊断。在9个中心采访了1，208名患者。对任何物质的共病依赖的终生发生率在英国最高（35%），但在德国（21%）和法国（19%）要低得多，通常是去年发生率的两倍多。对酒精和其他精神活性物质的依赖表现出类似的变化（共病酒精依赖：英国26%;德国18%;法国14%;共病药物依赖：英国18%;德国8%;法国7%）。在控制了个体特征后，国家内部的差异仍然存在。依赖的相对几率高于一般人群，但因国家和中心而异。依赖障碍是西欧精神分裂症患者的一个常见问题，尽管尚未制定有效的服务配置。总体而言，这些欧洲发生率低于美国报告的发生率。需要对目前患有并发症的人与那些不再依赖的人进行比较研究。
Relatively little is known about rates of comorbid drug and alcohol problems in people with schizophrenia outside the USA. Most studies have recruited from single countries. Newly available data provided an unmatched opportunity to investigate the prevalence of comorbid dependence on alcohol and other psychoactive substances in people with schizophrenia in France, Germany and the UK at the same time. The European Schizophrenia Cohort study data set used semi-structured clinical interviews to establish DSM-IV diagnoses. 1,208 patients were interviewed in nine centres. The lifetime rate for comorbid dependence on any substance was highest in the UK (35 %), but considerably lower in Germany (21 %) and in France (19 %), and generally more than double the past-year rates. Dependence on alcohol and on other psychoactive substances showed similar variations (comorbid alcohol dependence: UK 26 %; Germany 18 %; France 14 %; comorbid drug dependence: UK 18 %; Germany 8 %; France 7 %). Differences within countries persisted after controlling for individual characteristics. The relative odds of dependence were higher than in the general population, but varied between countries and centres. Dependence disorders are a common problem in people with schizophrenia in Western Europe, although effective service configurations have yet to be developed. Overall, these European rates are less than those reported from the USA. Research comparing people with current comorbidity with those who are no longer dependent is needed.