Extensive abnormality of brain white matter integrity in pathological gambling
Extensive abnormality of brain white matter integrity in pathological gambling
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DOI：
10.1016/j.pscychresns.2011.08.001
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发表时间：
2011-12-30
影响因子：
2.3
通讯作者：
Kaasinen, Valtteri
中科院分区：
文献类型：
--
作者：
Joutsa, Juho;Saunavaara, Jani;Kaasinen, Valtteri
几项关于物质使用障碍的磁共振成像(MRI)研究显示，大脑白质完整性异常，但还没有关于病理性赌博的研究，这是行为成瘾的一种形式。我们的目的是调查病态赌徒与健康对照组相比，脑部灰质和白质体积以及轴突白质完整性的可能变化。24名受试者(12名临床诊断为男性病态赌徒和12名年龄匹配的健康男性志愿者)接受了结构和扩散加权脑MRI扫描，并使用基于体素的形态测量和基于区域的空间统计进行分析。在病理性赌徒中，白质完整性较低(分数各向异性较低，平均弥散系数较高)见于多个脑区，包括胼胝体、扣带、上纵束、下额枕束、内囊前肢、丘脑前束、下纵束和钩状/下额枕束。在病态赌徒和对照组之间，灰质或白质的体积没有差异。结果表明，病理性赌博与几条脑白质束的完整性普遍降低有关。这种扩散异常与之前在药物成瘾患者中的发现非常相似。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Several magnetic resonance imaging (MRI) studies in substance use disorders have shown brain white matter integrity abnormalities, but there are no studies in pathological gambling, a form of behavioral addiction. Our objective was to investigate possible changes in regional brain gray and white matter volumes, and axonal white matter integrity in pathological gamblers compared to healthy controls. Twenty-four subjects (12 clinically diagnosed male pathological gamblers and 12 age-matched healthy male volunteers) underwent structural and diffusion weighted brain MRI scans, which were analyzed with voxel-based morphometry and tract based spatial statistics. In pathological gamblers, widespread lower white matter integrity (lower fractional anisotropy, higher mean diffusivity) was seen in multiple brain regions including the corpus callosum, the cingulum, the superior longitudinal fascicle, the inferior fronto-occipital fascicle, the anterior limb of internal capsule, the anterior thalamic radiation, the inferior longitudinal fascicle and the uncinate/inferior fronto-occipital fascicle. There were no volumetric differences in gray or white matter between pathological gamblers and controls. The results suggest that pathological gambling is associated with extensive lower integrity of several brain white matter tracts. The diffusion abnormality closely resembles previous findings in individuals with substance addictions. (C) 2011 Elsevier Ireland Ltd. All rights reserved.