Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging.
Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging.
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无痴呆老年人的中晚年体力活动和神经精神症状：梅奥诊所衰老研究。
DOI：
10.1176/appi.neuropsych.20220068
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Vassilaki,M
中科院分区：
文献类型：
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作者：
Krell-Roesch,Janina;Syrjanen,JeremyA;Bezold,Jelena;Trautwein,Sandra;Barisch-Fritz,Bettina;Kremers,WalterK;Fields,JulieA;Scharf,EugeneL;Knopman,DavidS;Stokin,GorazdB;Petersen,RonaldC;Jekauc,Darko;Woll,Alexander;Vassilaki,M
本研究探讨了体力活动（PA）和神经精神症状（NST）之间的关联在老年人免费dementions.MethodsThis横断面研究包括3,222人≥70岁（1,655名男性;平均值±SD年龄=79.2±5.6;认知未受损，N=2,723;轻度认知功能障碍，N=499）从人口为基础的马约诊所老龄化研究。中年时的PA（作为假定的预测因素）（即，当参与者为50-65岁时）和晚年（即，评估前一年）采用自我报告的有效问卷进行评估; PA强度和频率用于计算综合评分。采用神经精神量表、贝克抑郁量表（BDI-II）和贝克焦虑量表（BAI）评估患者的焦虑程度（作为假定结局）。回归分析包括中年和晚年的PA在每个模型中，这是调整了年龄，性别，教育，载脂蛋白E144的状态，和医疗comorhistory.ResultsHigher晚年PA与较低的几率有冷漠（OR=0.89，95%CI =0.84-0.93），食欲改变（OR=0.92，95%CI =0.87-0.98），夜间干扰（OR=0.95，95%CI =0.91-0.99），抑郁（OR=0.94，95%CI =0.90-0.97），易激惹（OR=0.93，95%CI =0.89-0.97），临床抑郁症（OR=0.92，95%CI =0.88-0.97），临床焦虑（OR=0.90，95%CI =0.86-0.94），以及较低的BDI-II（β估计值=−0.042，95%CI =−0.051至−0.033）和BAI（β估计值=−0.030，95%CI =−0.040至−0.021）评分。较高的中年PA仅与较高的BDI-II评分相关（β估计值=0.011，95% CI=0.004至0.019）。性别之间的关联修改PA和prednis.ConclusionsLate-life PA与临床抑郁症或焦虑症和亚临床抑郁症的可能性较低。这些发现需要在队列研究中得到证实。
ObjectiveThis study examined associations between physical activity (PA) and neuropsychiatric symptoms (NPS) in older adults free of dementia.MethodsThis cross-sectional study included 3,222 individuals ≥70 years of age (1,655 men; mean±SD age=79.2±5.6; cognitively unimpaired, N=2,723; mild cognitive impairment, N=499) from the population-based Mayo Clinic Study of Aging. PA (taken as a presumed predictor) in midlife (i.e., when participants were 50–65 years of age) and late life (i.e., the year prior to assessment) was assessed with a self-reported, validated questionnaire; PA intensity and frequency were used to calculate composite scores. NPS (taken as presumed outcomes) were assessed with the Neuropsychiatric Inventory Questionnaire, Beck Depression Inventory (BDI-II), and Beck Anxiety Inventory (BAI). Regression analyses included midlife and late-life PA in each model, which were adjusted for age, sex, education, apolipoprotein E ɛ4 status, and medical comorbidity.ResultsHigher late-life PA was associated with lower odds of having apathy (OR=0.89, 95% CI=0.84–0.93), appetite changes (OR=0.92, 95% CI=0.87–0.98), nighttime disturbances (OR=0.95, 95% CI=0.91–0.99), depression (OR=0.94, 95% CI=0.90–0.97), irritability (OR=0.93, 95% CI=0.89–0.97), clinical depression (OR=0.92, 95% CI=0.88–0.97), and clinical anxiety (OR=0.90, 95% CI=0.86–0.94), as well as lower BDI-II (β estimate=−0.042, 95% CI=−0.051 to −0.033) and BAI (β estimate=−0.030, 95% CI=−0.040 to −0.021) scores. Higher midlife PA was associated only with higher BDI-II scores (β estimate=0.011, 95% CI=0.004 to 0.019). Sex modified the associations between PA and NPS.ConclusionsLate-life PA was associated with a lower likelihood of clinical depression or anxiety and subclinical NPS. These findings need to be confirmed in a cohort study.