A unique function for cyclin D3 in early B cell development
A unique function for cyclin D3 in early B cell development
复制标题
DOI：
10.1038/ni1324
复制
发表时间：
2006-05-01
影响因子：
30.5
通讯作者：
Aifantis, I
中科院分区：
文献类型：
--
作者：
Cooper, AB;Sawai, CM;Aifantis, I
在造血过程中，干细胞增殖依赖于D型细胞周期蛋白的表达。然而，很少有人知道如何每个细胞周期蛋白D有助于特定的造血谱系的发展。在这里，对Ccnd 1（-/-）、Ccnd 2（-/-）、Ccnd 3（-/-）和Ccnd 2（-/-）Ccnd 3（-/-）小鼠的分析表明，细胞周期蛋白D3是前B细胞发育所唯一需要的。Ccnd 3的转录依赖于共同γ链的表达。相反，前B细胞受体的表达和“下游”信号通路的激活阻止了蛋白酶体介导的细胞周期蛋白D3的降解。细胞周期蛋白D3通过整合细胞因子和前B细胞受体依赖性信号以扩增已成功重排免疫球蛋白重链的前B细胞库，在B细胞发育中具有关键功能。
During hematopoiesis, stem cell proliferation is dependent on expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Here, analysis of Ccnd1(-/-), Ccnd2(-/-), Ccnd3(-/-) and Ccnd2(-/-) Ccnd3(-/-) mice showed that cyclin D3 was uniquely required for the development of pre-B cells. Transcription of Ccnd3 was dependent on expression of the common gamma-chain. In contrast, expression of the pre-B cell receptor and activation of 'downstream' signaling pathways prevented proteasome-mediated degradation of cyclin D3. Cyclin D3 has a key function in B cell development by integrating cytokine and pre-B cell receptor-dependent signals to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain.