Impaired interactions among white-matter functional networks in antipsychotic-naive first-episode schizophrenia
Impaired interactions among white-matter functional networks in antipsychotic-naive first-episode schizophrenia
复制标题
初治首发精神分裂症患者白质功能网络之间的相互作用受损
DOI：
10.1002/hbm.24801
复制
发表时间：
2019-10-01
影响因子：
4.8
通讯作者：
Chen, Huafu
中科院分区：
文献类型：
--
作者：
Fan, Yun-Shuang;Li, Zehan;Chen, Huafu
精神分裂症被认为是一种由大脑中白质纤维的结构性病理改变引起的疾病。然而，很少有研究集中在精神分裂症的白质功能变化。考虑到越来越多的证据表明，白质静息态功能磁共振成像（rsfMRI）信号可以有效地描绘神经元活动和精神病理状态，本研究探讨白质网络水平的相互作用，在抗精神病药初治的首发精神分裂症（FES），以促进精神病理机制的解释精神分裂症。我们招募了42名FES患者（FES）和38名健康对照（HC），所有这些患者都接受了rsfMRI。我们确定了11个白质功能网络，可以进一步分为深层，中层和浅层网络。然后，我们使用系数格兰杰因果关系分析研究了这11个白质功能网络之间的网络水平的相互作用。我们使用基于网络的统计方法对11个网络之间的影响进行了分组比较。与HC相比，FES的中上级冠状辐射网络对眶额浅层和深层网络的兴奋性影响被破坏。此外，在FES中观察到浅表网络（包括额顶网络、颞额网络和眶额网络）内的额外抑制失败。我们还从另一个中心招募了一个独立的队列（13名FES和13名HC），以检查我们的研究结果在各中心的可复制性。相似的重复实验结果进一步验证了精神分裂症的白质功能网络相互作用模型。精神分裂症患者白质功能网络之间相互作用受损的新发现表明，精神分裂症的病理生理学也可能在于白质功能异常。
Schizophrenia has been conceptualized as a disorder arising from structurally pathological alterations to white-matter fibers in the brain. However, few studies have focused on white-matter functional changes in schizophrenia. Considering that converging evidence suggests that white-matter resting state functional MRI (rsfMRI) signals can effectively depict neuronal activity and psychopathological status, this study examined white-matter network-level interactions in antipsychotic-naive first-episode schizophrenia (FES) to facilitate the interpretation of the psychiatric pathological mechanisms in schizophrenia. We recruited 42 FES patients (FESs) and 38 healthy controls (HCs), all of whom underwent rsfMRI. We identified 11 white-matter functional networks, which could be further classified into deep, middle, and superficial layers of networks. We then examined network-level interactions among these 11 white-matter functional networks using coefficient Granger causality analysis. We employed group comparisons on the influences among 11 networks using network-based statistic. Excitatory influences from the middle superior corona radiate network to the superficial orbitofrontal and deep networks were disrupted in FESs compared with HCs. Additionally, an extra failure of suppression within superficial networks (including the frontoparietal network, temporofrontal network, and the orbitofrontal network) was observed in FESs. We additionally recruited an independent cohort (13 FESs and 13 HCs) from another center to examine the replicability of our findings across centers. Similar replication results further verified the white-matter functional network interaction model of schizophrenia. The novel findings of impaired interactions among white-matter functional networks in schizophrenia indicate that the pathophysiology of schizophrenia may also lie in white-matter functional abnormalities.