Physiologically Realistic and Validated Mathematical Liver Model Revels Hepatobiliary Transfer Rates for Gd-EOB-DTPA Using Human DCE-MRI Data
Physiologically Realistic and Validated Mathematical Liver Model Revels Hepatobiliary Transfer Rates for Gd-EOB-DTPA Using Human DCE-MRI Data
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DOI：
10.1371/journal.pone.0095700
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发表时间：
2014-04-18
期刊：
影响因子：
3.7
通讯作者：
Lundberg, Peter
中科院分区：
文献类型：
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作者：
Forsgren, Mikael Fredrik;Leinhard, Olof Dahlqvist;Lundberg, Peter
目的：弥漫性肝病（DLD），如非酒精性脂肪性肝病（NASH）和肝硬化，是整个西方世界迅速增长的问题。基于肝细胞特异性造影剂（CA）Gd-EOB-DTPA摄取的磁共振成像（MRI）是诊断DLD的一种有前途的非侵入性方法。然而，为了充分利用这种动态测量的潜力，用于临床或研究目的，更先进的方法，数据analysis.Methods：一个数学模型，可以用于这样的数据分析开发。使用具有高空间分辨率的临床方案从健康人类受试者获得数据。该模型是基于常微分方程和超越局部扩散建模，考虑到完整的系统访问CA。结果：所提出的模型可以准确地描述数据，这是证实了卡方统计。此外，该模型是最小的和可识别的，这意味着所有参数的确定具有很小的不确定性。该模型也验证了使用独立data.Conclusions：我们已经开发出一种新的方法，用于确定以前未描述的生理肝脏参数在人类中，与CA运输整个肝脏。该方法具有在患有DLD和肝功能受损的患者的临床检查中评估局部肝功能的潜力。
Objectives: Diffuse liver disease (DLD), such as non-alcoholic fatty liver disease (NASH) and cirrhosis, is a rapidly growing problem throughout the Westernized world. Magnetic resonance imaging (MRI), based on uptake of the hepatocyte-specific contrast agent (CA) Gd-EOB-DTPA, is a promising non-invasive approach for diagnosing DLD. However, to fully utilize the potential of such dynamic measurements for clinical or research purposes, more advanced methods for data analysis are required.Methods: A mathematical model that can be used for such data-analysis was developed. Data was obtained from healthy human subjects using a clinical protocol with high spatial resolution. The model is based on ordinary differential equations and goes beyond local diffusion modeling, taking into account the complete system accessible to the CA.Results: The presented model can describe the data accurately, which was confirmed using chi-square statistics. Furthermore, the model is minimal and identifiable, meaning that all parameters were determined with small degree of uncertainty. The model was also validated using independent data.Conclusions: We have developed a novel approach for determining previously undescribed physiological hepatic parameters in humans, associated with CA transport across the liver. The method has a potential for assessing regional liver function in clinical examinations of patients that are suffering of DLD and compromised hepatic function.