Ontogeny of the stretch response in the rat fetus: kappa opioid involvement.
Ontogeny of the stretch response in the rat fetus: kappa opioid involvement.
复制标题
大鼠胎儿拉伸反应的个体发育：卡帕阿片类药物的参与。
DOI：
10.1037//0735-7044.107.2.370
复制
发表时间：
1993
影响因子：
1.9
通讯作者：
Smotherman,WP
中科院分区：
文献类型：
--
作者：
Andersen,SL;Robinson,SR;Smotherman,WP
先前的研究表明，κ阿片系统是功能性的，并在妊娠第21天介导大鼠胎儿的牵拉反应中发挥作用。在本研究中，在第19、20或21天给予κ阿片受体激动剂（U50，488），并在输注乳汁或生理盐水后记录胎仔行为。在第20天和第21天，κ阿片样物质系统的激活促进了对生理盐水的拉伸反应。虽然第19天的胎儿没有伸展，但录像带分析表明，κ阿片类药物操作促进了后肢活动的适度增加和胎儿身体姿势的变化，这些变化通常发生在伸展之前。这些发现表明，κ阿片系统的功能成熟可能是胎儿牵拉反应表达的限制因素。（PsycInfo数据库记录（c）2016阿帕，保留所有权利）
Previous studies have demonstrated that the kappa opioid system is functional and plays a role in mediating the stretch response of the rat fetus on Day 21 of gestation. In this study, a kappa opioid agonist (U50, 488) was administered on Days 19, 20, or 21, and fetal behavior was recorded after infusion of either milk or saline. Activation of the kappa opioid system promoted stretching in response to saline on Days 20 and 21. Although fetuses on Day 19 did not stretch, videotape analysis indicated that kappa opioid manipulation promoted modest increases in rearlimb activity and changes in fetal body posture that typically occur antecedent to the stretch. These findings suggest that functional maturity of the kappa opioid system may be a limiting factor in the expression of the fetal stretch response.(PsycINFO Database Record (c) 2016 APA, all rights reserved)