Understanding Podocyte Biology to Develop Novel Kidney Therapeutics.
Understanding Podocyte Biology to Develop Novel Kidney Therapeutics.
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DOI：
10.3389/fendo.2018.00409
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发表时间：
2018
影响因子：
5.2
通讯作者：
Patrakka J
中科院分区：
文献类型：
--
作者：
Lal MA;Patrakka J
在过去的二十年中，越来越清楚的是，足细胞的损伤和丢失是许多形式的肾小球病和慢性肾脏疾病的早期和常见的临床观察。许多足细胞表达基因中致病单基因突变的鉴定以及使用临床前动物模型进行的研究表明，足细胞在建立肾功能障碍中起着核心作用。在这篇综述中，我们总结了目前关于足细胞靶向治疗潜力的知识，并就如何更深入地了解足细胞的分子组成将使未来的治疗干预成为可能给出了我们的观点。具体来说，我们叙述了一些目前描述的足细胞中心治疗策略，并总结了各种模型系统的现状和演变，这些模型系统用于促进我们对足细胞生物学的分子和功能基础的理解。
Over the past two decades it has become increasing clear that injury and loss of podocytes is an early and common clinical observation presented in many forms of glomerulopathy and chronic kidney disease. Identification of disease-causing monogenic mutations in numerous podocyte-expressed genes as well as studies conducted using preclinical animal models have shown that the podocyte plays a central role in establishing kidney dysfunction. In this review, we summarize current knowledge regarding the potential for podocyte-targeted therapies and give our view on how a deeper understanding of the molecular makeup of the podocyte will enable future therapeutic interventions. Specifically, we recount some of the currently described podocentric strategies for therapy and summarize the status and evolution of various model systems used to facilitate our understanding of the molecular and functional underpinnings of podocyte biology.