Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer
Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer
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DOI：
10.1016/j.biocel.2017.06.011
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发表时间：
2017-08-01
影响因子：
4
通讯作者：
Yang, Shu
中科院分区：
文献类型：
--
作者：
Galper, Jasmin;Rayner, Stephanie L.;Yang, Shu
Cyclin F 由 CCNF 编码，是 Skp1-Cul1-F-box E3 泛素连接酶复合物 SCFcyclin (F) 的底物识别组件。 E3 泛素连接酶在泛素蛋白酶体介导的蛋白质降解中发挥关键作用，蛋白质降解是细胞内蛋白质稳态机制的重要组成部分。通过识别和调节多种蛋白质底物的可用性，SCFcyclin F 在调节各种细胞过程中发挥作用，包括 DNA 的复制和修复以及细胞周期检查点控制。细胞周期蛋白 F 功能障碍与多种形式的癌症有关，CCNF 突变最近与家族性和散发性肌萎缩侧索硬化症和额颞叶痴呆有关，为了解神经退行性病变的致病机制提供了新的线索。在这篇综述中，我们评估了有关 cyclin F 功能的现有文献，重点关注其在癌症和神经退行性变中的作用。
Cyclin F, encoded by CCNF, is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex, SCFcyclin (F). E3 ubiquitin ligases play a key role in ubiquitin-proteasome mediated protein degradation, an essential component of protein homeostatic mechanisms within the cell. By recognising and regulating the availability of several protein substrates, SCFcyclin F plays a role in regulating various cellular processes including replication and repair of DNA and cell cycle checkpoint control. Cyclin F dysfunction has been implicated in various forms of cancer and CCNF mutations were recently linked to familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia, offering a new lead to understanding the pathogenic mechanisms underlying neurodegeneration. In this review, we evaluate the current literature on the function of cyclin F with an emphasis on its roles in cancer and neurodegeneration.