Ligand-Enabled Arylation of γ-C-H Bonds.
Ligand-Enabled Arylation of γ-C-H Bonds.
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DOI：
10.1002/anie.201512020
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发表时间：
2016-03-18
期刊：
影响因子：
--
通讯作者：
Yu JQ
中科院分区：
文献类型：
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作者：
Li S;Zhu RY;Xiao KJ;Yu JQ
以喹啉为配体，Pd（II）催化脂肪酸酰胺的γ-C（sp3）-H键芳基化反应。利用该方法从天然氨基酸制备了多种γ-芳基-α-氨基酸。配体结构对反应活性的影响也进行了系统的研究。
Pd(II)-catalyzed arylation of γ-C(sp3)–H bond of aliphatic acid-derived amides is developed by using quinoline-based ligands. Various γ-aryl-α-amino acids are prepared from natural amino acids using this method. The influence of ligand structure on reactivity is also systematically investigated.