Bacterial spore detection by [Tb3+(macrocycle)(dipicolinate)] luminescence
Bacterial spore detection by [Tb3+(macrocycle)(dipicolinate)] luminescence
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DOI：
10.1021/ja061831t
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发表时间：
2007-02-14
影响因子：
15
通讯作者：
Ponce, Adrian
中科院分区：
文献类型：
--
作者：
Cable, Morgan L.;Kirby, James P.;Ponce, Adrian
二吡啶酸（DPA）是芽孢杆菌（Bacillus）和梭状芽孢杆菌（Clostridium）的一种休眠形式，是细菌孢子的一种独特成分，可以通过DPA触发Tb3+发光来检测。由于排除了配位水分子，[Tb(DO2A)]（+）比Tb3+(aq)提高了细菌孢子检测的敏感性，这是构建具有增强结合选择性的DPA受体位点的第一步。对标题三元[Tb(DO2A)(DPA)]（-）配合物进行了结构表征，并以两个DO2A-DPA配体间氢相互作用稳定配合物为特征。
Dipicolinic acid (DPA) is a unique constituent of bacterial spores, a dormant form of Bacillus and Clostridium, which can be detected using DPA-triggered Tb3+ luminescence. [Tb(DO2A)](+) improves the sensitivity of bacterial spore detection over Tb3+(aq) owing to the exclusion of coordinated water molecules and represents the first step toward construction of a DPA receptor site with enhanced binding selectivity. The title ternary [Tb(DO2A)(DPA)](-) complex was structurally characterized and features two DO2A-DPA interligand hydrogen interactions that stabilize the complex.