Self-renewal of hematopoietic and leukemic stem cells:: a central role for the Polycomb-group gene Bmi-1
Self-renewal of hematopoietic and leukemic stem cells:: a central role for the Polycomb-group gene Bmi-1
复制标题
DOI：
10.1016/s1471-4906(03)00241-2
复制
发表时间：
2003-10-01
影响因子：
16.8
通讯作者：
Raaphorst, FM
中科院分区：
文献类型：
--
作者：
Raaphorst, FM
造血干细胞的自我更新对于维持每日血细胞的生产至关重要。最近的两项研究表明，多梳组基因Bmi-1是不可或缺的正常和白血病干细胞的自我更新的调节。这将Polycomb组基因确定为白血病治疗干预的潜在靶点，可能还有其他形式的癌症。
Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. Two recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal by normal and leukemic stem cells. This identifies Polycomb-group genes as potential targets for therapeutic intervention in leukemia, and possibly other forms of cancer.