Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice.
Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice.
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作者：
S. Ng;W. Figg
背景前列腺癌是美国男性癌症死亡的第二大原因。转移性前列腺癌的治疗选择有限。在这种恶性肿瘤的治疗中使用草药疗法仍然存在争议。材料与方法我们测试了五种中草药补充剂FB、FM、PP、HF和FBL101，它们含有多种天然药物的不同组合，如甘草、黑升麻、冬瓜、独角兽和黄荆根提取物、小茴香籽提取物、红三叶花提取物以及染料木素和谷维素，对荷CWR22R和PC3前列腺癌移植瘤的严重联合免疫缺陷小鼠具有抗肿瘤活性。并对其作用机制进行了探讨。结果FB、FM、PP、HF和FBL101对PC3肿瘤生长的抑制率分别为53%、75%、80%、81%和87%。在CWR22R肿瘤中，所有补充剂都观察到类似的生长抑制。与未经处理的对照组相比，补充剂对血浆总睾酮水平没有显著影响。PP和FBL101分别显著降低PC3和CWR22R肿瘤中的VEGF水平。在所有五种补充剂治疗的PC3肿瘤中，肿瘤内微血管密度降低，但仅在接受HF治疗的CWR22R肿瘤中。结论含上述提取物的中药补充剂可抑制前列腺癌移植瘤的生长，可能部分是通过抗血管生成机制实现的。这些草药补充剂作为前列腺癌预防和治疗药物的潜在用途值得进一步研究。
BACKGROUND Prostate cancer is the second leading cause of cancer death in American men. Therapeutic options for metastatic prostate cancer are limited. The use of herbal therapies in the treatment of this malignancy remains controversial. MATERIALS AND METHODS We tested five herbal supplements, designated FB, FM, PP, HF and FBL101, which contain different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root extracts, fennel seed extract, red clover blossoms extract as well as genistein and gamma oryzanol, for antitumor activity in severely combined immunodeficient mice bearing CWR22R and PC3 prostate cancer xenografts. Their mechanisms of action were also explored. RESULTS FB, FM, PP, HF and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81% and 87%, respectively. In CWR22R tumors, similar growth suppression was observed with all supplements. Total plasma testosterone levels were not significantly altered by the supplements relative to the untreated control. PP and FBL101 significantly reduced VEGF levels in PC3 and CWR22R tumors, respectively. Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF. CONCLUSION Our results demonstrated that herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms. The potential use of these herbal supplements as preventive and therapeutic agents in prostate cancer warrants further investigation.