Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.
Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.
复制标题
编码人 1 型血管紧张素 II 受体的 cDNA 的分子克隆、序列分析和表达。
DOI：
10.1016/0006-291x(92)90570-b
复制
发表时间：
1992
影响因子：
3.1
通讯作者：
H. Nawata
中科院分区：
文献类型：
--
作者：
R. Takayanagi;K. Ohnaka;Y. Sakai;R. Nakao;T. Yanase;M. Haji;T. Inagami;Hiroaki Furuta;Deng Fu Gou;M. Nakamuta;H. Nawata
我们从人肝脏cDNA文库中分离到一个编码1型血管紧张素II受体的cDNA。cDNA有一个开放阅读框，编码一个359个氨基酸残基的蛋白，相对Mr为41,060。推导出的人血管紧张素II （Ang II）受体氨基酸序列与牛和大鼠1型Ang II受体氨基酸序列的相似性分别为95.3%和94.2%，与G蛋白偶联受体具有显著的相似性。与os -7细胞中表达的受体结合的排列顺序为Ang II b> Ang III > Ang i。在人肝、肺、肾上腺和肾上腺皮质腺瘤中均检测到Ang II受体mRNA的表达，但在肾上腺髓质肿瘤、嗜铬细胞瘤中未检测到。
We isolated a cDNA encoding type-1 angiotensin II receptor from a human liver cDNA library. The cDNA had an open reading frame encoding a protein of 359 amino acid residues with a relative Mr of 41,060. The deduced amino acid sequence of the human angiotensin II (Ang II) receptor was 95.3% and 94.2% identical to those of bovine and rat type-1 Ang II receptors, respectively, and had a significant similarity with the G protein-coupled receptor. The rank order of the binding to the receptor expressed in COS-7 cells was Ang II > Ang III > Ang I. The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis.
牛肾上腺皮质细胞中心房钠尿因子受体的两种不同形式。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Takayanagi,R;Inagami,T;Snajdar,RM;Imada,T;Tamura,M;Misono,KS
通讯作者：
Misono,KS
影响因子：
15.9
作者：
NAFTILAN, AJ;PRATT, RE;DZAU, VJ
通讯作者：
DZAU, VJ