Circulating adiponectin and endometrial cancer risk
Circulating adiponectin and endometrial cancer risk
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DOI：
10.1210/jc.2003-031716
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发表时间：
2004-03-01
影响因子：
5.8
通讯作者：
La Vecchia, C
中科院分区：
文献类型：
--
作者：
Dal Maso, L;Augustin, LSA;La Vecchia, C
脂联素是一种具有胰岛素敏感特性的激素，其循环水平在与肥胖和高胰岛素血症相关的疾病中降低，这是子宫内膜癌的公认危险因素。1999年至2002年期间，在意大利东北部，对87例经组织学证实的子宫内膜癌患者和132例因急性非肿瘤性疾病入院的对照组进行了访谈，并采集了血液样本。脂联素的水平通过RIA的方式在样品中进行评价。血浆脂联素水平与子宫内膜癌风险呈负相关[比值比（OR），0.42; 95%置信区间，0.19 - 0.94]，比较最高与最低三分位数。血清脂联素也出现了类似的结果（OR，0.30; 95%置信区间，0.14 - 0.68）。绝经前妇女的相关性强于绝经后妇女，但在体重指数（BMI）或产次分层中未观察到显著异质性。根据乘法模型，BMI和脂联素对子宫内膜癌的风险具有独立影响（BMI最高水平和脂联素最低水平的OR为6.45）。
Circulating levels of adiponectin, a hormone with insulin-sensitizing properties, are decreased in conditions related to obesity and hyperinsulinemia, which are recognized risk factors for endometrial cancer. Eighty-seven cases with incident, histologically confirmed endometrial cancer and 132 controls admitted for acute, nonneoplastic diseases were interviewed in northeastern Italy between 1999 and 2002, and blood samples were collected. Levels of adiponectin were evaluated in samples by means of a RIA. An inverse association with endometrial cancer risk emerged for plasma adiponectin levels [ odds ratio (OR), 0.42; 95% confidence interval, 0.19 - 0.94] when comparing the highest vs. the lowest tertiles. Similar results emerged for serum adiponectin ( OR, 0.30; 95% confidence interval, 0.14 - 0.68). The association was stronger in pre- than in postmenopausal women, but no significant heterogeneity was observed across strata of body mass index (BMI) or parity. BMI and adiponectin showed independent effects on the risk of endometrial cancer according to a multiplicative model ( OR, 6.45 in the highest level of BMI and in the lowest one of adiponectin).