N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: substituent effects on subtype selectivity.
N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: substituent effects on subtype selectivity.
复制标题
DOI：
10.1248/cpb.52.1021
复制
发表时间：
2004-08
影响因子：
1.7
通讯作者：
H. Sano;T. Noguchi;Aya Tanatani;H. Miyachi;Y. Hashimoto
中科院分区：
文献类型：
--
作者：
H. Sano;T. Noguchi;Aya Tanatani;H. Miyachi;Y. Hashimoto
以沙利度胺为先导化合物，在结构开发研究过程中合成了几种具有环氧合酶（考克斯）抑制活性的N-取代苯基邻苯二甲酰亚胺和苯基高邻苯二甲酰亚胺衍生物。研究了取代基对亚型选择性的影响。
Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.