Thrombospondin-4 in tissue remodeling.
Thrombospondin-4 in tissue remodeling.
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DOI：
10.1016/j.matbio.2017.11.006
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Plow EF
中科院分区：
文献类型：
--
作者：
Stenina-Adognravi O;Plow EF
凝血酶敏感蛋白-4(TSP-4)属于凝血酶敏感蛋白家族，由5个高度同源的成员组成。最近，TSP-4在心血管和神经系统、炎症、癌症和运动单位中具有许多新的功能，这引起了人们对这种细胞外基质(ECM)蛋白的关注。这些新发现的功能使TSP-4有别于其他凝血酶原蛋白。例如，TSP-4促进血管生成，而其他TSP要么阻止血管生成，要么对新血管生长没有影响；TSP-4减少纤维化和胶原产生，而TSP-1和TSP-2促进几个器官的纤维化；与其他TSP不同，TSP-4似乎在ECM中具有一些结构功能。目前关于TSP-4在不同器官和生理系统中功能的研究表明，这种进化上保守的蛋白是胚胎发育和损伤反应过程中细胞外基质(ECM)组织和生产以及组织重塑的主要调节因子。本文就TSP-4的性质和功能作一综述，并讨论其在组织重塑中的作用。
Thrombospondin-4 (TSP-4) belongs to the thrombospondin protein family that consists of five highly homologous members. A number of novel functions have been recently assigned to TSP-4 in cardiovascular and nervous systems, inflammation, cancer, and the motor unit, which have attracted attention to this extracellular matrix (ECM) protein. These newly discovered functions set TSP-4 apart from other thrombospondins. For example, TSP-4 promotes angiogenesis while other TSPs either prevent it or have no effect on new blood vessel growth; TSP-4 reduces fibrosis and collagen production while TSP-1 and TSP-2 promote fibrosis in several organs; unlike other TSPs, TSP-4 appears to have some structural functions in ECM. The current information about TSP-4 functions in different organs and physiological systems suggests that this evolutionary conserved protein is a major regulator of the extracellular matrix (ECM) organization and production and tissue remodeling during the embryonic development and response to injury. In this review article, we summarize the properties and functions of TSP-4 and discuss its role in tissue remodeling.
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