Temporal Convergence of Dynamic Cell Assemblies in the Striato-Pallidal Network
Temporal Convergence of Dynamic Cell Assemblies in the Striato-Pallidal Network
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DOI：
10.1523/jneurosci.4830-11.2012
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发表时间：
2012-02-15
影响因子：
5.3
通讯作者：
Bergman, Hagai
中科院分区：
文献类型：
--
作者：
Adler, Avital;Katabi, Shiran;Bergman, Hagai
假设基底节(BG)实现了一种强化学习算法。然而，目前还不清楚信息是如何沿着这个网络处理的，从而使它能够发挥其功能作用。在这里，我们提出了三种不同的视觉线索编码方案，与BG神经元群体的奖赏、中性和厌恶结果相关。我们研究了两个群体的投射神经元[纹状体中棘神经元(MSN)和苍白球外段神经元(GPE)]和一个神经调制组[纹状体强直活动神经元(TANS)]的反应谱和动力学行为。MSNS和GPE神经元表现出持续的平均活动，以提示呈现。MSN的群体平均反应由三个不同的反应组组成，这些反应组在时间上是不同的，并在试验过程中在连续的事件中被激发。在GPE中，平均持续反应由两个反应组组成，这两个反应组主要通过发射速度方向的即时变化来区分。然而，与MSN不同的是，两个GPE反应组的神经元都显示出持续的长时间和时间重叠的持续活动。壳核TANS的刻板反应以单一的瞬时反应群为特征。最后，由于不同的任务事件反映在不同的反应组中，MSN和GPE反应组在结果阶段进行了重组，我们的结果加强了BG神经调节剂和主轴神经元之间的功能分离。此外，他们还揭示了行为灵长类动物纹状体网络中细胞组合的动态变化。最后，它们支持MSN响应组到GPE细胞的功能融合。
The basal ganglia (BG) have been hypothesized to implement a reinforcement learning algorithm. However, it is not clear how information is processed along this network, thus enabling it to perform its functional role. Here we present three different encoding schemes of visual cues associated with rewarding, neutral, and aversive outcomes by BG neuronal populations.We studied the response profile and dynamical behavior of two populations of projection neurons [striatal medium spiny neurons (MSNs), and neurons in the external segment of the globus pallidus (GPe)], and one neuromodulator group [striatal tonically active neurons (TANs)] from behaving monkeys. MSNs and GPe neurons displayed sustained average activity to cue presentation. The population average response of MSNs was composed of three distinct response groups that were temporally differentiated and fired in serial episodes along the trial. In the GPe, the average sustained response was composed of two response groups that were primarily differentiated by their immediate change in firing rate direction. However, unlike MSNs, neurons in both GPe response groups displayed prolonged and temporally overlapping persistent activity. The putamen TANs stereotyped response was characterized by a single transient response group. Finally, the MSN and GPe response groups reorganized at the outcome epoch, as different task events were reflected in different response groups.Our results strengthen the functional separation between BG neuromodulators and main axis neurons. Furthermore, they reveal dynamically changing cell assemblies in the striatal network of behaving primates. Finally, they support the functional convergence of the MSN response groups onto GPe cells.