Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis.
Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis.
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DOI：
10.1186/s13058-016-0746-9
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发表时间：
2016-08-23
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影响因子：
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通讯作者：
Gierach GL
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作者：
Felix AS;Lenz P;Pfeiffer RM;Hewitt SM;Morris J;Patel DA;Geller B;Vacek PM;Weaver DL;Chicoine RE;Shepherd J;Mahmoudzadeh AP;Wang J;Fan B;Malkov S;Herschorn SD;Johnson JM;Cora RL;Brinton LA;Sherman ME;Gierach GL
乳房X线摄影密度（MD）高的女性患乳腺癌的风险增加了四到六倍;然而，大多数人既没有流行的肿瘤，也不会发展成肿瘤。磁共振成像（MRI）研究表明，背景实质增强，血管分布的指标，与乳腺癌的风险增加。组织中微血管密度（MVD）、MD和活检诊断的相关性尚未确定，我们调查了218名接受活检的妇女的这些关系。通过计数三个代表性区域乳腺活检组织全切片中的CD 31阳性血管来确定MVD;将平均MVD转换为近似正态分布。使用数字化乳房X线照片，我们用单次X线吸收法定量MD体积。我们使用线性回归来评估MVD和MD之间的相关性，调整了年龄和体重指数（BMI），并按活检诊断分层：病例（原位癌或浸润性癌，n = 44）与非病例（非增殖性或增殖性良性乳腺疾病，n = 174）。采用经年龄、BMI和MD校正的Logistic回归计算MVD与活检诊断之间相关性的比值比（OR）和95%置信区间（CI）。我们还评估了MD与乳腺癌的关联是否因MD而异。MVD和MD并不一致。较高的MVD与较高的原位/浸润性疾病几率显著相关（OR调整后= 1.69，95%CI = 1.17-2.44）。MVD与乳腺癌的关联在非致密体积较大的女性中最强。组织中MVD增加与乳腺癌相关，与MD无关，与MRI结果一致，提示其可能作为放射学癌症生物标志物的价值。本文的在线版本（doi：10.1186/s13058-016-0746-9）包含补充材料，可供授权用户使用。
Women with high levels of mammographic density (MD) have a four- to six-fold increased risk of developing breast cancer; however, most neither have a prevalent tumor nor will they develop one. Magnetic resonance imaging (MRI) studies suggest that background parenchymal enhancement, an indicator of vascularity, is related to increased breast cancer risk. Correlations of microvessel density (MVD) in tissue, MD and biopsy diagnosis have not been defined, and we investigated these relationships among 218 women referred for biopsy. MVD was determined by counting CD31-positive vessels in whole sections of breast biopsies in three representative areas; average MVD was transformed to approximate normality. Using digital mammograms, we quantified MD volume with single X-ray absorptiometry. We used linear regression to evaluate associations between MVD and MD adjusted for age and body mass index (BMI) overall, and stratified by biopsy diagnosis: cases (in situ or invasive cancer, n = 44) versus non-cases (non-proliferative or proliferative benign breast disease, n = 174). Logistic regression adjusted for age, BMI, and MD was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for associations between MVD and biopsy diagnosis. We also assessed whether the MVD-breast cancer association varied by MD. MVD and MD were not consistently associated. Higher MVD was significantly associated with higher odds of in situ/invasive disease (ORAdjusted = 1.69, 95 % CI = 1.17–2.44). MVD-breast cancer associations were strongest among women with greater non-dense volume. Increased MVD in tissues is associated with breast cancer, independently of MD, consistent with MRI findings suggestive of its possible value as a radiological cancer biomarker. The online version of this article (doi:10.1186/s13058-016-0746-9) contains supplementary material, which is available to authorized users.