Emodin and Its Role in Chronic Diseases
Emodin and Its Role in Chronic Diseases
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DOI：
10.1007/978-3-319-41334-1_3
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Tiku, Ashu Bhan
中科院分区：
文献类型：
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作者：
Monisha, B. Anu;Kumar, Niraj;Tiku, Ashu Bhan
心脏病、中风、癌症、呼吸系统疾病和糖尿病等疾病是迄今为止世界上最主要的死亡原因，占所有死亡人数的60%。尽管已经取得了巨大的医学进步并提出了许多治疗方法，但传统医学和药用植物在治疗中仍占有重要地位。他们一直为各种健康问题提供宝贵的解决方案。大黄素（1,3,8-三羟基-6-甲基蒽醌）是一种天然蒽醌衍生物，存在于多种中药材中。传统上，它被用作许多草药泻药的活性成分。然而，在过去的几年里，在细胞和分子水平上研究大黄素的生物学效应已经取得了重大进展，它正在成为一种重要的治疗药物。本综述概述了大黄素在各种疾病和细胞信号通路中的调节作用，这可能对其未来的临床应用产生重要影响。
Diseases, such as heart disease, stroke, cancer, respiratory diseases, and diabetes, are by far the leading cause of mortality in the world, representing 60 % of all deaths. Although substantial medical advances have been made and many therapeutic approaches proposed yet traditional medicine and medicinal plants find an important place in therapy. They have been providing invaluable solutions to the various health problems. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural anthraquinone derivative found in various Chinese medicinal herbs. Traditionally, it has been used as an active constituent of many herbal laxatives. However, in the last few years, significant progress has been made in studying the biological effects of emodin at cellular and molecular levels and it is emerging as an important therapeutic agent. This review provides an overview of the modulatory effects of emodin in various diseases and cell signaling pathways, which may have important implications in its future clinical use.