The UCLA High-Risk Project.
The UCLA High-Risk Project.
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加州大学洛杉矶分校的高风险项目。
DOI：
10.1093/schbul/13.3.505
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发表时间：
1987
影响因子：
6.6
通讯作者：
M. Goldstein
中科院分区：
文献类型：
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作者：
M. Goldstein
加州大学洛杉矶分校的高风险项目在15年的随访期内研究了64个家庭的队列。在研究开始时，每个家庭都有一个有行为困难的青少年，他们需要从心理诊所寻求帮助。精神分裂症的危险程度的两个标准最初设计，一个是基于青少年的问题的形式和其他的父母的属性的沟通偏差（CD），情感风格（AS），和表达的情绪（EE）。据推测，精神分裂症将是可能的结果，当某些模式的青少年障碍和消极的沟通和情感模式存在于家庭中。64个家庭中有54个家庭的指数后代在15年内成功随访（末次随访时平均年龄= 30岁），并进行了盲态精神病诊断。与最初的假设相反，青少年问题的形式具有有限的预后价值;然而，CD和AS的组合正确地识别了绝大多数发展为精神分裂症和相关疾病的病例。如果因变量是家族中任何后代患精神分裂症谱系障碍的风险，则CD的表现甚至更好。
The UCLA High Risk Project studied a cohort of 64 families over a 15-year followup period. At entry to the study, the families each contained one adolescent who was having behavioral difficulties for whom help was sought from a psychological clinic. Two criteria of the degree of risk for schizophrenia were devised initially, one based on the form of the adolescent's problem and the other on the parental attributes of communication deviance (CD), affective style (AS), and expressed emotion (EE). It was hypothesized that schizophrenia would be the likely outcome when certain patterns of adolescent disturbance and negative communicational and affective patterns were present in the family. The index offspring of 54 of the 64 families were successfully followed up over the 15-year period (mean age = 30 at last followup), and blind psychiatric diagnoses were done. Contrary to the initial hypothesis, the form of the adolescent problem had limited prognostic value; however, the combination of CD and AS correctly identified the overwhelming number of cases who developed schizophrenia and related disorders. CD did even better if the dependent variable was the risk for schizophrenia spectrum disorder in any offspring in the family.
影响因子：
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作者：
Doane,JA;West,KL;Goldstein,MJ;Rodnick,EH;Jones,JE
通讯作者：
Jones,JE
终生精神病诊断的最佳估计：方法学研究。
影响因子：
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作者：
Leckman,JF;Sholomskas,D;Thompson,WD;Belanger,A;Weissman,MM
通讯作者：
Weissman,MM