Adult Cortical Plasticity Studied with Chronically Implanted Electrode Arrays
Adult Cortical Plasticity Studied with Chronically Implanted Electrode Arrays
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DOI：
10.1523/jneurosci.3579-14.2015
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发表时间：
2015-02-11
影响因子：
5.3
通讯作者：
Gilbert, Charles D.
中科院分区：
文献类型：
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作者：
Abe, Hiroshi;McManus, Justin N. J.;Gilbert, Charles D.
成年人大脑皮层的功能结构保留了依赖经验的变化能力。这在局灶性双眼病变后可见，表现为初级视觉皮层（V1）中病变投射区（LPZ）的感受野（RF）的快速变化。为了纵向研究这些变化背后的电路动态，我们在猕猴（Macaca mulatta）V1中植入微电极阵列，消除了采样偏差的可能性，这是以前研究中的一个问题。用这种方法，我们观察到一个快速的初始恢复在LPZ，在接下来的几周内，63-89%的网站在LPZ显示恢复的视觉反应与显着的位置调整。RF偏离暗点约3度。在没有病变的情况下，视觉刺激周围的人工暗点并没有引起视觉反应，这表明损伤后的RF移位导致皮层重组。有趣的是，尽管尖峰和LFP都提供了一致的病变前位置调整，但只有尖峰反映了病变后的重新映射。
The functional architecture of adult cerebral cortex retains a capacity for experience-dependent change. This is seen after focal binocular lesions as rapid changes in receptive field (RF) of the lesion projection zone (LPZ) in the primary visual cortex (V1). To study the dynamics of the circuitry underlying these changes longitudinally, we implanted microelectrode arrays in macaque (Macaca mulatta) V1, eliminating the possibility of sampling bias, which was a concern in previous studies. With this method, we observed a rapid initial recovery in the LPZ and, during the following weeks, 63-89% of the sites in the LPZ showed recovery of visual responses with significant position tuning. The RFs shifted similar to 3 degrees away from the scotoma. In the absence of a lesion, visual stimulation surrounding an artificial scotoma did not elicit visual responses, suggesting that the postlesion RF shifts resulted from cortical reorganization. Interestingly, although both spikes and LFPs gave consistent prelesion position tuning, only spikes reflected the postlesion remapping.