The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.
The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.
复制标题
DOI：
10.1021/ol702952n
复制
发表时间：
2008-02-21
期刊：
影响因子：
5.2
通讯作者：
Fenical, William
中科院分区：
文献类型：
--
作者：
Hughes, Chambers C.;Prieto-Davo, Alejandra;Fenical, William
培养专性海洋链霉菌菌株提供了marinopyrroles A和B，密集卤化，轴向手性代谢产物，含有一个不常见的双吡咯结构。marinopyrrole B的X-射线分析表明，天然产物以M-构型的阻转对映体存在。虽然在室温下构型稳定，但M（-）-marinopyrrole A可以在高温下外消旋化，得到非天然的P-（+）-atropo-enantiomer。marinopyrroles对耐甲氧西林金黄色葡萄球菌具有有效的抗生素活性。
Cultivation of an obligate marine Streptomyces strain has furnished the marinopyrroles A and B, densely halogenated, axially chiral metabolites that contain an uncommon bispyrrole structure. X-ray analysis of marinopyrrole B showed that the natural product exists as an atropoenantiomer with the M-configuration. Though configurationally stable at room temperature, M(-)-marinopyrrole A can be racemized at elevated temperatures to yield the non-natural P-(+)-atropo-enantiomer. The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus.