Clinical characteristics and fetal outcomes in women with epilepsy with planned and unplanned pregnancy: A retrospective study
Clinical characteristics and fetal outcomes in women with epilepsy with planned and unplanned pregnancy: A retrospective study
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计划内和计划外妊娠的癫痫女性的临床特征和胎儿结局：一项回顾性研究
DOI：
10.1016/j.seizure.2020.05.011
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发表时间：
2020-07-01
影响因子：
3
通讯作者：
Jiang, Wen
中科院分区：
文献类型：
--
作者：
Zhang, Yao-yao;Song, Chang-geng;Jiang, Wen
目的：比较癫痫妇女(WWE)计划妊娠与计划外妊娠(WWE)的抗癫痫药物(AED)治疗方式、癫痫发作控制及叶酸补充情况，探讨计划妊娠对胎儿结局的影响。方法：对2010年2月至2018年12月前瞻性收集的WWE妊娠资料进行回顾性分析。计划妊娠被定义为从预期怀孕到分娩期间由癫痫专家定期监督的WWE。比较计划妊娠组和计划外妊娠组的临床特征和胎儿结局。结果：共有188例计划内妊娠和289例计划外妊娠进入本研究。在计划怀孕中，66.0%接受AED单一治疗，32.4%接受综合治疗。在计划外妊娠中，58.1%没有服用抗癫痫药物，28.0%接受单一治疗，12.8%接受综合治疗。计划妊娠的强直-阵挛发作较少(P=0.002)，无发作的比例较高(41.0%vs.22.8%；P
Purpose: To compare the antiepileptic drug (AED) treatment patterns, seizure control, and folic acid supplementation between planned and unplanned pregnancy in women with epilepsy (WWE) and to investigate the effects of planned pregnancy on fetal outcomes.Methods: A prospectively collected database including WWE with pregnancy from Feb 2010 to Dec 2018 was retrospectively analyzed. Planned pregnancy was defined as WWE being regularly supervised by epileptologists from the time of intended pregnancy until delivery. Clinical characteristics and fetal outcomes were compared between the planned and unplanned pregnancy groups. Logistic regression was used to identify modifiable factors associated with adverse fetal outcomes.Results: A total of 188 planned pregnancies and 289 unplanned pregnancies were enrolled in our study. Among planned pregnancies, 66.0 % took AED monotherapy, and 32.4 % received polytherapy. Among unplanned pregnancies, 58.1 % didn't take AEDs, 28.0 % took monotherapy, and 12.8 % received polytherapy. The planned pregnancies had less generalized tonic-clonic seizures (P=0.002) and higher proportion of being seizure-free (41.0 % vs. 22.8 %; P