Relationship between lipids and bone mass in 2 cohorts of healthy women and men
Relationship between lipids and bone mass in 2 cohorts of healthy women and men
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DOI：
10.1007/s00223-003-0050-4
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发表时间：
2004-04-01
影响因子：
4.2
通讯作者：
Battaglia, E
中科院分区：
文献类型：
--
作者：
Adami, S;Braga, V;Battaglia, E
最近的一些研究结果似乎表明，脂肪和骨骼代谢密切相关。我们调查了236名绝经前或绝经后的妇女，年龄在35-81岁之间，在我们的骨质疏松症中心（“临床组”）脂质谱和骨密度（BMD）之间的关系。为了验证结果的一致性，还研究了参加基于人群的流行病学调查（“社区队列”）的265名男性和481名女性，年龄在68-75岁之间。采用双能x线骨密度仪（DXA）测量腰椎、股骨颈、全髋和全身骨密度、全身脂肪、%脂肪质量和瘦质量。临床组腰椎、髋部BMD Z评分值与各项血脂测量值均有较强相关性：HDL胆固醇（P < 0.05）、载脂蛋白A （P < 0.000）呈负相关，LDL胆固醇（P < 0.05）、载脂蛋白B （P < 0.001）、甘油三酯（P < 0.05）呈正相关。当BMD值根据体重和BMI进行调整时，大多数关系仍然具有统计学意义。在社区队列中，男性和女性的总体和髋部骨密度值与年龄、体重、身高、BMI、脂肪质量、瘦质量、脂肪质量%密切相关。女性和男性的全身和髋部骨密度与血脂有显著相关性。高密度脂蛋白胆固醇呈负相关，总胆固醇、甘油三酯和低密度脂蛋白胆固醇呈正相关。大多数关系（甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白/高密度脂蛋白胆固醇的女性比例，以及所有测量的男性脂质）在BMD值调整为人体测量值（体重、身高、脂肪量）时仍然具有统计学意义（P值范围从0.000到0.03）。这项研究首次表明，无论在男性还是女性中，脂质谱都与骨量密切相关。这种关联的解释仍然是假设的，但它可能为理解控制骨代谢的机制开辟新的视角。
A number of recent findings seem to indicate that fat and bone metabolism are strictly connected. We investigated the relationship between lipid profile and bone mineral density (BMD) in 236 either pre- or postmenopausal women, aged 35-81 years, attending our osteoporosis center ("clinic group"). In order to verify the consistency of the results, 265 men and 481 women aged 68-75, participating in a population-based epidemiological investigation ("community cohort"), were also studied. Lumbar spine, femoral neck, total hip and total body BMD, total body fat, % fat mass and lean mass were measured using dual energy X-ray absorptiometry (DXA). In the clinic group, lumbar spine and hip BMD Z score values were both strongly related to all measured serum lipids: the relationship was negative for HDL cholesterol (P < 0.05) and Apo A lipoprotein (P < 0.000) and positive for LDL cholesterol (P < 0.05), Apo B lipoprotein (P < 0.001) and triglycerides (P < 0.05). When BMD values were adjusted for body weight and BMI, most relationships remained statistically significant. In the community cohort, total body and hip BMD values were strongly related in both men and women to age, body weight, height, BMI, fat mass, lean mass, % fat mass. Total body and hip BMD were significantly related to serum lipids in both women and men. The relationship was negative for HDL cholesterol and positive for total cholesterol, triglycerides and LDL cholesterol. Most of these relationships (triglycerides, HDL cholesterol, LDL/HDL cholesterol ratio in women, and all measured lipids in men) remained statistically significant (P values ranging from 0.000 to 0.03) when the BMD values were adjusted also for anthropometric measures (body weight, height, fat mass). This study demonstrates for the first time that the lipid profile is strictly related to bone mass in both men and women. The interpretation of this association remains hypothetical but it might open new perspectives for understanding the mechanisms controlling bone metabolism.