The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer.
The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer.
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上皮间质转化（EMT）和癌症干细胞：对胰腺癌治疗耐药的影响
DOI：
10.1186/s12943-017-0624-9
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发表时间：
2017-02-28
期刊：
影响因子：
37.3
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Zhou P;Li B;Liu F;Zhang M;Wang Q;Liu Y;Yao Y;Li D
上皮间质转化（EMT）的机械特性和具有干细胞特性的胰腺癌亚群已越来越多地被认为是治疗效果的有效调节剂。特别是，胰腺癌干细胞（PCSC）在肿瘤复发和治疗抵抗期间具有重要的功能。本文综述了EMT和PCSC在胰腺癌进展、转移和耐药中的作用，以及EMT和PCSC与生化信号整合的机制和参与胰腺癌耐药的潜在途径。这些发现强调了在肿瘤形成、进展和对治疗的反应期间确认胰腺癌中控制EMT和癌症干细胞的干细胞标志物和复杂分子信号通路的重要性。
The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer during tumor formation, progression, and response to therapy.