A detailed atlas of chick heart development in vivo
A detailed atlas of chick heart development in vivo
复制标题
DOI：
10.1016/j.aanat.2012.10.011
复制
发表时间：
2013-01-01
影响因子：
2.2
通讯作者：
Yelbuz, T. Mesud
中科院分区：
文献类型：
--
作者：
Al Naieb, Sarah;Happel, Christoph M.;Yelbuz, T. Mesud
过去已经研究了各种模式生物，如小鼠，非洲爪蟾或斑马鱼胚胎，以深入了解驱动脊椎动物心脏正常和异常发育的复杂过程。尽管鸡胚胎几个世纪以来一直是胚胎学家和心血管科学家青睐的经典模型系统，用于说明基本脊椎动物胚胎学和心血管发育的原理，但到目前为止，还没有人用（a）图像和（B）提供该模型中从早期视觉阶段到完全形成的心脏阶段的心脏发育的完整文献心脏跳动的录像然而，心脏发育阶段的体内记录是必不可少的，因为最初的管状胚胎心脏不仅经历了巨大的形态变化，而且在心脏发生过程中也发生了有趣的功能变化，只有当它们遵循并保持在正常的发育途径中，在这项工作中，我们提出了第一个参考目录的心脏发育在体内与（1）25张来自Hamburger-Hamilton（HH）第12阶段的不同视角的高分辨率彩色图像板（第2天，相对直的心管，早期心肌收缩）通过HH-阶段35（第9天，四腔心脏）在舒张末期和收缩末期，包括所有这些阶段的概述板;（2）收集了82个心脏跳动的视频记录，这些视频记录对应于图中所示的阶段的不同视图。(C)2012 Elsevier GmbH. All rights reserved.
Various model organisms such as mouse, xenopus, or zebrafish embryos have been studied in the past to gain insight into the complex processes driving normal and abnormal development of the vertebrate heart. Despite the fact that the chicken embryo has been a favored classic model system used by embryologists and cardiovascular scientists for centuries to illustrate the principles of basic vertebrate embryology and cardiovascular development, so far, no one has provided a thorough documentation of heart development in this model from early visual stages to the stage of a completely formed heart with (a) images and (b) video recordings of beating hearts. However, in vivo documentation of heart development stages is indispensable because the initially tubular embryonic heart not only undergoes dramatic morphological changes, but also intriguing functional changes during cardiogenesis, which, only if they follow and remain within the normal developmental pathway, lead to the establishment of the normal four-chambered heart.In this work we present the first reference catalogue of cardiac development in vivo with (1) 25 plates of high resolution colour images in different views from Hamburger-Hamilton (HH)-stage 12 (day 2, relatively straight heart tube, early myocardial contractions) through HH-stage 35 (day 9, four-chambered heart) in end-diastole and end-systole, including a plate with an overview of all these stages; (2) collection of 82 video recordings of beating hearts in different views corresponding to the stages shown in the plates. (C) 2012 Elsevier GmbH. All rights reserved.