Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
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DOI：
10.1056/nejm199704033361401
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发表时间：
1997-04-03
影响因子：
158.5
通讯作者：
Hennekens, CH
中科院分区：
文献类型：
--
作者：
Ridker, PM;Cushman, M;Hennekens, CH
背景 炎症在动脉粥样硬化血栓形成的发病机制中可能很重要。我们研究了炎症是否会增加首次血栓形成事件的风险，以及阿司匹林治疗是否会降低风险。 方法 我们测量了参与医生健康研究的 543 名表面健康的男性（随后出现心肌梗死、中风或静脉血栓形成）和 543 名在治疗期间未报告血管疾病的研究参与者的血浆 C 反应蛋白（全身性炎症的标志物）。 随访时间超过八年。受试者在试验开始时被随机分配接受阿司匹林或安慰剂。 结果 发生心肌梗塞的男性的基线血浆 C 反应蛋白浓度较高（1.51 毫克/升 vs. 1.13 毫克/升，P
Background Inflammation may be important in the pathogenesis of atherothrombosis. We studied whether inflammation increases the risk of a first thrombotic event and whether treatment with aspirin decreases the risk.Methods We measured plasma C-reactive protein, a marker for systemic inflammation, in 543 apparently healthy men participating in the Physicians' Health Study in whom myocardial infarction, stroke, or venous thrombosis subsequently developed, and in 543 study participants who did not report vascular disease during a follow-up period exceeding eight years. Subjects were randomly assigned to receive aspirin or placebo at the beginning of the trial.Results Base-line plasma C-reactive protein concentrations were higher among men who went on to have myocardial infarction (1.51 vs. 1.13 mg per liter, P