Freeze-dried jaboticaba peel added to high-fat diet increases HDL-cholesterol and improves insulin resistance in obese rats
Freeze-dried jaboticaba peel added to high-fat diet increases HDL-cholesterol and improves insulin resistance in obese rats
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DOI：
10.1016/j.foodres.2012.07.052
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发表时间：
2012-11
影响因子：
8.1
通讯作者：
S. A. Lenquiste;Â. Batista;R. S. Marineli;N. Dragano;M. Maróstica
中科院分区：
文献类型：
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作者：
S. A. Lenquiste;Â. Batista;R. S. Marineli;N. Dragano;M. Maróstica
Jaboticaba（Myrciaria spp.）是一种巴西水果，果皮中含有高浓度的花青素，具有抗氧化作用，并可能对肥胖和胰岛素抵抗有益。本研究的目的是评估高脂饮食中添加冻干贾博蒂卡果皮 (FJP) 对肥胖和胰岛素抵抗的影响。 Sprague-Dawley 大鼠分别喂食对照饮食、高脂饮食 (HF) 和添加 1%、2% 和 4% FJP 的 HF 饮食。测定能量摄入、体重增加、身体成分、血糖、血脂和激素状况。测定葡萄糖耐量、胰岛素耐量和HOMA-IR指数。服用 1%、2% 和 4% FJP 会降低血清胰岛素（分别为 47%、57% 和 52%）和 HOMA-IR（分别为 40%、54% 和 48%）。此外，与 HF 对照相比，2% FJP 可使 HDL 胆固醇水平增加 41.65%。其他参数没有显着变化。总之，食用 FJP 可以增加实验动物的 HDL 胆固醇并改善胰岛素抵抗。
Jaboticaba (Myrciaria spp.) is a Brazilian fruit with high concentrations of anthocyanins in the peel which have shown antioxidant effects and possible benefits on obesity and insulin resistance. The objective of this study was to evaluate the effect of freeze-dried jaboticaba peel (FJP) added to high-fat diet on the development of obesity and insulin resistance. Sprague–Dawley rats were fed control diet, high-fat diet (HF) and HF diets added with 1, 2 and 4% of FJP. Energy intake, weight gain, body composition, serum glucose, and lipid and hormonal profiles were determined. Glucose tolerance, insulin tolerance and HOMA-IR index were determined. The consumption of 1, 2 and 4% FJP reduced serum insulin (47, 57 and 52%, respectively) and HOMA-IR (40, 54 and 48%, respectively). In addition, 2% FJP showed to increase HDL-cholesterol levels by 41.65% compared to HF control. Other parameters showed no significant changes. In conclusion, the consumption of FJP showed to increase HDL-cholesterol and improve insulin resistance in experimental animals.