DNA microarray gene expression analysis of human vascular endothelial cells exposed to arsenite
DNA microarray gene expression analysis of human vascular endothelial cells exposed to arsenite
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DOI：
10.2131/jts.35.275
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发表时间：
2010-04-01
影响因子：
2
通讯作者：
Satoh, Masahiko
中科院分区：
文献类型：
--
作者：
Fujiwara, Yasuyuki;Honda, Akiko;Satoh, Masahiko
DNA 微阵列用于监测人脑微血管内皮细胞 (HBMEC) 和人冠状动脉内皮细胞 (HCAEC) 对亚砷酸钠 (iAs(III)) 的转录反应。 iAs(III)分别增强HBMEC和HCAEC中10个和6个基因的表达，降低45个和20个基因的表达。在64个表达发生变化的基因中，HBMEC和HCAEC共有5个上调基因和12个下调基因。
DNA microarray was used to monitor the transcriptional response of human brain microvascular endothelial cells (HBMEC) and human coronary artery endothelial cells (HCAEC) to sodium arsenite (iAs(III)). iAs(III) enhanced the expression of 10 and 6 genes, and reduced the expression of 45 and 20 genes in HBMEC and HCAEC, respectively. Among the 64 genes whose expression was changed in some way, HBMEC and HCAEC had 5 up-regulated and 12 down-regulated genes in common.