Stress and re-stress increases conditioned taste aversion learning in rats: Possible frontal cortical and hippocampal muscarinic receptor involvement
Stress and re-stress increases conditioned taste aversion learning in rats: Possible frontal cortical and hippocampal muscarinic receptor involvement
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DOI：
10.1016/j.ejphar.2008.03.004
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发表时间：
2008-05-31
影响因子：
5
通讯作者：
Harvey, Brian H.
中科院分区：
文献类型：
--
作者：
Brand, Linda;Groenewald, Ilse;Harvey, Brian H.
创伤后应激障碍的症状往往是由视觉、听觉、嗅觉和味觉“闪回”形式的感官线索引起的，导致恐惧记忆强化和重新体验、回避和过度觉醒的特征性症状。单次长时间应激和无再应激已被用于探索这种疾病的神经生物学，特别是在上下文条件反射和空间记忆障碍方面。然而，较少的工作已经做了联想感觉相关的记忆与厌恶的事件。虽然越来越多的证据支持胆碱能途径在应激中的作用，但尚未在上述动物模型中进行研究。我们研究了单次长时间应激和无再应激对大鼠条件性味觉厌恶学习的影响，并对额叶皮层和海马[H-3]-奎宁环苄酯（[H-3]-QNB）毒蕈碱受体结合进行了差异分析。单一的长时间的压力和不重新强调都增强联想感官厌恶学习7天后，压力-味觉配对，虽然重新强调没有加强这种反应。增加皮层和海马毒蕈碱受体密度（B-max）被发现7天后，单次长时间的应力与再应力，虽然受体亲和力保持不变。额叶皮层和海马毒蕈碱受体的变化，因此，在大鼠暴露于压力和再应激条件下的味觉厌恶学习的基础。这些数据表明，它可能是有用的，以研究胆碱能通路介导的联想记忆在精神疾病，如创伤后应激障碍的作用。(c)2008 Elsevier B. V.保留所有权利。
Symptoms of posttraumatic stress disorder are often precipitated by sensory cues in the form of visual, auditory, olfactory and gustatory "flashbacks" resulting in enhanced fear-memory consolidation and the characteristic symptoms of re-experiencing, avoidance and hyper-arousal. Single prolonged stress with and without re-stress have been used to explore the neurobiology of this disorder, particularly with respect to contextual conditioning and spatial memory impairment. However, less work has been done regarding associative sensory-related memories linked to aversive events. Although growing evidence supports a role for cholinergic pathways in stress, this has not been studied in the above animal models. We studied the effects of single prolonged stress with and without re-stress on conditioned taste aversion learning in rats, together with differential analysis of frontal cortical and hippocampal [H-3]quinuclidinyl benzylate ([H-3]-QNB) muscarinic receptor binding. Single prolonged stress with and without re-stress both enhanced associative sensory aversion learning 7 days after stressor-taste pairing, although re-stress did not strengthen this response. Increased cortical and hippocampal muscarinic receptor density (B-max) was found 7 days after single prolonged stress with re-stress, although receptor affinity remained unaltered. Frontal cortical and hippocampal muscarinic receptor changes may thus underlie conditioned taste aversion learning in rats exposed to stress and re-stress. These data suggest that it may be useful to study the role of cholinergic pathways in mediating associative memory in psychiatric disorders such as posttraumatic stress disorder. (c) 2008 Elsevier B.V. All rights reserved.