Neuropsychological and neurological function of human immunodeficiency virus seropositive asymptomatic individuals.
Neuropsychological and neurological function of human immunodeficiency virus seropositive asymptomatic individuals.
复制标题
人类免疫缺陷病毒血清阳性无症状个体的神经心理和神经功能。
作者：
K. E. Goethe;J. Mitchell;D. W. Marshall;Robin L. Brey;W. Cahill;G. Léger;L. Hoy;R. Boswell
尽管患有获得性免疫缺陷综合症（艾滋病）的个体在各种神经心理任务上经常受到损害，但在人类免疫缺陷病毒（HIV）感染过程中何时可以可靠地检测到神经心理衰退仍然存在问题。对 83 名免疫学和神经学完好的无症状 HIV 感染者进行了详细的神经心理学测试，这些人来自 649 名携带 HIV 抗体的美国空军人员。将这些无症状受试者与一组艾滋病毒阴性受试者进行比较，发现神经心理功能没有显着差异。在这些无症状受试者中，没有发现因脑脊液异常而导致的显着神经心理学差异。当分析中纳入 13 名免疫受损受试者的数据时，脑脊液值异常的受试者在语言记忆任务中的表现明显较差，这表明认知功能障碍是由免疫功能下降先兆的。讨论了抑制 HIV 相关认知障碍的发病率、患病率和自然史的方法学问题，以及表明先前发表的 HIV 相关痴呆频率的高估计值可能无法代表所有 HIV 感染人群的数据。
Although individuals with acquired immunodeficiency syndrome (AIDS) are often impaired on a variety of neuropsychological tasks, questions remain as to when neuropsychological decline can be reliably detected during the course of human immunodeficiency virus (HIV) infection. Detailed neuropsychological testing was accomplished on a cohort of 83 immunologically and neurologically intact asymptomatic HIV-infected individuals drawn from a larger pool of 649 US Air Force personnel with HIV antibodies. These asymptomatic subjects were compared with a group of HIV-negative subjects, and no significant differences in neuropsychological functioning were found. No significant neuropsychological differences were found as a function of cerebrospinal fluid abnormalities in these asymptomatic subjects. When data from 13 subjects with immune compromise were included in the analyses, those with abnormal cerebrospinal fluid values performed significantly poorer on a task of verbal memory, suggesting that cognitive dysfunction is antedated by immunological decline. Methodological problems that inhibit specification of the incidence, prevalence, and natural history of HIV-related cognitive impairment are discussed, as are data suggesting that previously published high estimates of the frequency of HIV-related dementia may not be representative of all HIV-infected populations.