Metabolic rate in the right amygdala predicts negative affect in depressed patients
Metabolic rate in the right amygdala predicts negative affect in depressed patients
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DOI：
10.1097/00001756-199810050-00028
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发表时间：
1998-10-05
期刊：
影响因子：
1.7
通讯作者：
Davidson, RJ
中科院分区：
文献类型：
--
作者：
Abercrombie, HC;Schaefer, SM;Davidson, RJ
研究了杏仁核在重度抑郁症中的作用。用[F-18]氟脱氧葡萄糖正电子发射断层扫描(PET)测定两组受试者的静息脑局部代谢率(rCMR(Glu))。样本分别包括10名和17名非药物抑郁症患者和11名和13名对照。利用PET和磁共振图像的联合配准，分别为杏仁核和丘脑划定区域，后者用作对照区域。抑郁组大鼠右侧杏仁核rCMR(Glu)。与负性情绪呈正相关。丘脑RCM(Glu)与负性情绪无关，杏仁核RCMR(Glu)对抑郁症患者负性情绪得分的贡献高于丘脑RCMR(Glu)。(C)1998年，Lippincott Williams&Wilkins。
THE role of the amygdala in major depression was investigated. Resting regional cerebral metabolic rate (rCMR(glu)) was measured with [F-18]fluorodeoxyglucose positron emission tomography (PET) in two samples of subjects using two different PET cameras. The samples consisted of 10 and 17 medication-free depressives and 11 and 13 controls, respectively. Using coregistration of PET and magnetic resonance images, regions were individually delineated for the amygdala and thalamus, the latter of which was used as a control region. Within the depressed groups, right amygdalar rCMR(glu). was positively correlated with negative affect. Thalamic rCM(glu) was not related to negative affect, and amygdalar rCMR(glu) accounted for a significant portion variance in depressives' negative affect scores over and above the contribution of thalamic rCMR(glu). (C) 1998 Lippincott Williams & Wilkins.