Longitudinal development of prefrontal function during early childhood
Longitudinal development of prefrontal function during early childhood
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DOI：
10.1016/j.dcn.2010.12.004
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发表时间：
2011-04-01
影响因子：
4.7
通讯作者：
Hiraki, Kazuo
中科院分区：
文献类型：
--
作者：
Moriguchi, Yusuke;Hiraki, Kazuo
本研究是一项关于幼儿前额叶功能发展的纵向研究。据观察，前额叶区域在儿童早期发育迅速。为了阐明这一发展，我们给儿童认知转移任务相关的前额叶功能在3岁（时间1）和4岁（时间2）。然后，我们监测行为表现的发展变化，并使用近红外光谱检查前额叶激活。我们发现，儿童在时间2比时间I表现出更好的行为表现和明显更强的下额叶激活。此外，我们证明了个体差异的前额叶激活相同的行为任务。在时间1的任务中表现更好的儿童在时间I显示出右下前额叶区域的显著激活，在时间2显示出双侧下前额叶区域的显著激活。在时间1表现较差的儿童在时间1没有表现出显著的下前额叶激活，但在时间2表现出显著的左下前额叶激活。这些结果表明，纵向方法来解决认知和神经发育之间的联系的重要性。(C)2011爱思唯尔有限公司保留所有权利。
This is a longitudinal study on development of prefrontal function in young children. Prefrontal areas have been observed to develop dramatically during early childhood. To elucidate this development, we gave children cognitive shifting tasks related to prefrontal function at 3 years of age (Time 1) and 4 years of age (Time 2). We then monitored developmental changes in behavioral performance and examined prefrontal activation using near infrared spectroscopy. We found that children showed better behavioral performance and significantly stronger inferior prefrontal activation at Time 2 than they did at Time I. Moreover, we demonstrated individual differences in prefrontal activation for the same behavioral tasks. Children who performed better in tasks at Time 1 showed significant activation of the right inferior prefrontal regions at Time I and significant activation of the bilateral inferior prefrontal regions at Time 2. Children who showed poorer performance at Time 1 exhibited no significant inferior prefrontal activation at Time 1 but significant left inferior prefrontal activation at Time 2. These results indicate the importance of the longitudinal method to address the link between cognitive and neural development. (C) 2011 Elsevier Ltd. All rights reserved.