Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa
Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa
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DOI：
10.1039/c2cc32549g
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Aono, Shigetoshi
中科院分区：
文献类型：
--
作者：
Sawai, Hitomi;Sugimoto, Hiroshi;Aono, Shigetoshi
铜绿假单胞菌信号转导蛋白Aer2由含血红素PAS和di-HAMP结构域组成的截短结构表明，远端色氨酸残基（Trp283）在稳定血红素结合的O-2和O-2结合后的分子内信号转导中起重要作用。
The crystal structure of a truncated Aer2, a signal transducer protein from Pseudomonas aeruginosa, consisting of the heme-containing PAS and di-HAMP domains revealed that a distal tryptophan residue (Trp283) plays an important role in stabilizing the heme-bound O-2 and intra-molecular signal transduction upon O-2 binding.