The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
复制标题
DOI：
10.1038/jhg.2010.75
复制
发表时间：
2010-09-01
影响因子：
3.5
通讯作者：
Osawa, Haruhiko
中科院分区：
文献类型：
--
作者：
Onuma, Hiroshi;Tabara, Yasuharu;Osawa, Haruhiko
最近有报道称，GCKR rs780094 与不同种族人群的空腹血糖（FPG）和甘油三酯（TG）水平相关（低 FPG 和高 TG 的 A 等位基因）。还报道了 GCKR rs780094 与 2 型糖尿病 (T2DM)（低风险等位基因）之间的关联。我们通过分析 488 例病例和 398 例对照，研究了日本受试者中 GCKR rs780094 与 T2DM 之间的关联。对之前的两项关联研究进行了荟萃分析。我们还分析了日本普通人群 (n=1854) 中单核苷酸多态性与临床参数之间的关联。在病例对照研究中，GCKR rs780094的A等位基因与T2DM风险降低相关（比值比=0.711（95%置信区间=0.589-0.859），P=4.2 x 10(-4)）。一项荟萃分析证实了 GCKR rs780094 与 T2DM 易感性之间的关联。在日本普通人群中，A/A 基因型受试者的 FPG、空腹血浆胰岛素和胰岛素抵抗稳态模型评估水平低于 G/G 基因型受试者。相反，具有 A/A 基因型的受试者比具有 G/G 基因型的受试者具有更高的 TG 水平。我们复制了 GCKR rs780094 作为日本受试者 T2DM 易感性的标记。这表明GCKR rs780094是各族群中T2DM易感性的常见变异。人类遗传学杂志 (2010) 55, 600-604; doi：10.1038/jhg.2010.75； 2010 年 6 月 24 日在线发布
It was recently reported that GCKR rs780094 was associated with fasting plasma glucose (FPG) and triglyceride (TG) levels in various ethnic populations (A allele for low FPG and high TG). An association between GCKR rs780094 and type 2 diabetes mellitus (T2DM) (A allele for low risk) has also been reported. We examined the association between GCKR rs780094 and T2DM in Japanese subjects by analyzing 488 cases and 398 controls. A meta-analysis was performed involving two previous association studies. We also analyzed the association between the single-nucleotide polymorphism and clinical parameters in the general Japanese population (n=1854). In the case-control study, the A allele of GCKR rs780094 was associated with a reduced risk of T2DM (odds ratio=0.711 (95% confidence interval=0.589-0.859), P=4.2 x 10(-4)). A meta-analysis confirmed the association of GCKR rs780094 with T2DM susceptibility. In the general Japanese population, subjects with the A/A genotype had lower levels of FPG, fasting plasma insulin and homeostasis model assessment of insulin resistance than those with the G/G genotype. Conversely, subjects with the A/A genotype had higher levels of TG than those with the G/G genotype. We replicated GCKR rs780094 as a marker of T2DM susceptibility in Japanese subjects. This suggests that GCKR rs780094 is a common variant for T2DM susceptibility in various ethnic groups. Journal of Human Genetics (2010) 55, 600-604; doi:10.1038/jhg.2010.75; published online 24 June 2010