RISK-FACTORS FOR CORONARY-ARTERY DISEASE IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
RISK-FACTORS FOR CORONARY-ARTERY DISEASE IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1016/0002-9343(92)90578-y
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发表时间：
1992-11-01
影响因子：
5.9
通讯作者：
HOCHBERG, MC
中科院分区：
文献类型：
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作者：
PETRI, M;PEREZGUTTHANN, S;HOCHBERG, MC
目得：在一项前瞻性纵向研究中，评估系统性红斑狼疮（SLE）患者冠状动脉疾病（CAD）的发生率并检查其危险因素。患者和方法：SLE患者被纳入约翰霍普金斯狼疮队列研究，这是一项对229例SLE患者结局的前瞻性研究。CAD定义为心绞痛、心肌梗死或猝死。每3个月前瞻性地获得关于CAD危险因素的数据，并使用单变量和多变量logistic回归进行分析。结果：截至1990年12月31日，229例SLE患者中有19例（8.3%）发生CAD，10例死亡中有3例（30%）。与无CAD的受试者相比，CAD患者在诊断SLE时（37.1岁vs 28.9岁，p = 0.004）和进入队列时（47.1岁vs 34.7岁，p = 0.004）更可能年龄较大。
PURPOSE: To estimate the frequency of and examine risk factors for coronary artery disease (CAD) in patients with systemic lupus erythematosus (SLE) in a prospective longitudinal study. PATIENTs AND METHODS: Patients with SLE are enrolled in The Johns Hopkins Lupus Cohort, a prospective study of outcomes in 229 subjects with SLE. CAD was defined as angina, myocardial infarction, or sudden death. Data on CAD risk factors were obtained prospectively every 3 months and were analyzed using univariate and multiple logistic regression. RESULTS: CAD occurred in 19 (8.3%) of 229 patients with SLE and accounted for 3 (30%) of 10 deaths as of December 31, 1990. Compared to subjects without CAD, those with CAD were more likely to have been older at both diagnosis of SLE (37.1 years versus 28.9 years, p = 0.004) and at entry into the cohort (47.1 years versus 34.7 years, p