Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading
Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading
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DOI：
10.1152/ajprenal.00254.2002
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发表时间：
2003-03-01
影响因子：
4.2
通讯作者：
Nielsen, S
中科院分区：
文献类型：
--
作者：
Frische, S;Kwon, TH;Nielsen, S
阴离子交换剂penddrin存在于B型和非a -非B插层细胞的顶质膜和连接小管中，参与HCO3-的分泌。在这项研究中，我们研究了pendrin的丰度和亚细胞定位是否受到实验性代谢性酸中毒和碱中毒的调节，并维持水和钠的摄入。NH4Cl负荷（0.033 mmol NH4Cl/g体wt，持续7天）显著降低了penddrin丰度，为对照值的22% +/-4% （n=6, P =6）
The anion exchanger pendrin is present in the apical plasma membrane of type B and non-A-non-B intercalated cells of the cortical collecting duct (CCD) and connecting tubule and is involved in HCO3- secretion. In this study, we investigated whether the abundance and subcellular localization of pendrin are regulated in response to experimental metabolic acidosis and alkalosis with maintained water and sodium intake. NH4Cl loading (0.033 mmol NH4Cl/g body wt for 7 days) dramatically reduced pendrin abundance to 22+/-4% of control values (n=6, P