Maximum-likelihood estimation of gene location by linkage disequilibrium.
Maximum-likelihood estimation of gene location by linkage disequilibrium.
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DOI：
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发表时间：
1994-04
影响因子：
9.8
通讯作者：
W. G. Hill;B. Weir
中科院分区：
文献类型：
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作者：
W. G. Hill;B. Weir
多态性疾病和作图标记之间的连锁不平衡D原则上可用于帮助找到疾病基因的作图位置。因此，根据样品中观察到的单倍型数量和群体参数Nc，推导出D值的可能性，其中N是有效群体大小，c是疾病和标记基因座之间的重组分数。的可能性计算明确的情况下，两个位点的杂合子优势，更一般地说，通过计算机模拟假设一个稳定的状态，恒定的人口规模和选择压力或中立。它被发现的可能性是，在一般情况下，不是很依赖于在基因座的选择的程度，是非常平坦的。这表明，从连锁不平衡的估计中无法获得关于图位的精确信息。
Linkage disequilibrium, D, between a polymorphic disease and mapped markers can, in principle, be used to help find the map position of the disease gene. Likelihoods are therefore derived for the value of D conditional on the observed number of haplotypes in the sample and on the population parameter Nc, where N is the effective population size and c the recombination fraction between the disease and marker loci. The likelihood is computed explicitly for the case of two loci with heterozygote superiority and, more generally, by computer simulations assuming a steady state of constant population size and selective pressures or neutrality. It is found that the likelihood is, in general, not very dependent on the degree of selection at the loci and is very flat. This suggests that precise information on map position will not be obtained from estimates of linkage disequilibrium.