Indomethacin and patent ductus arteriosus: effects on renal function in preterm lambs.
Indomethacin and patent ductus arteriosus: effects on renal function in preterm lambs.
复制标题
吲哚美辛和动脉导管未闭：对早产羔羊肾功能的影响。
DOI：
10.1152/ajprenal.1988.254.1.f38
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Roman,C
中科院分区：
文献类型：
--
作者：
Gleason,CA;Clyman,RI;Heymann,MA;Mauray,F;Leake,R;Roman,C
为了研究动脉导管未闭和吲哚美辛治疗对早产新生儿肾功能的独立影响，我们建立了一个可以调节导管直径的早产羔羊模型。我们研究了24只早产新生羔羊。8只羔羊（第1组）在分娩时关闭导管，未接受吲哚美辛。8只羊（组2）关闭其导管，然后在5.5 h时接受吲哚美辛（0.3 mg/kg）; 8只羊（组3）保持其导管开放，然后在5.5 h时接受吲哚美辛。在5 h（治疗前）和12.5 h进行血流动力学和肾功能测量。在第2组羔羊有一个显着减少菊粉清除率（GFR）和渗透压清除吲哚美辛后。与此相反，开放导管的羔羊（组3），当与封闭导管的羔羊（组1和2）在5小时，已经有显着降低血压，GFR，尿量，和渗透压清除率。吲哚美辛处理后，第3组羔羊的肾功能未进一步降低。我们认为，在未足月羔羊与未闭导管，明显缺乏肾功能不全后吲哚美辛治疗反映了潜在的肾功能下降。
To examine the independent effects of a patent ductus arteriosus and of indomethacin therapy on the renal function of the preterm newborn, we created a preterm lamb model in which ductus diameter could be regulated. We studied 24 preterm newborn lambs. Eight lambs (group 1) had their ductus closed at delivery and received no indomethacin. Eight lambs (group 2) had their ductus closed and then received indomethacin (0.3 mg/kg) at 5.5 h; eight lambs (group 3) had their ductus kept open and then received indomethacin at 5.5 h. Hemodynamic and renal function measurements were made at 5 h (pretreatment) and at 12.5 h. In group 2 lambs there was a significant reduction in inulin clearance (GFR) and osmolal clearance after indomethacin. In contrast, lambs with an open ductus (group 3), when compared with lambs with a closed ductus (groups 1 and 2) at 5 h, already had significantly decreased blood pressure, GFR, urine volume, and osmolal clearance. Following indomethacin treatment, group 3 lambs showed no further decrease in renal function. We suggest that in preterm lambs with patent ductus, the apparent lack of renal dysfunction following indomethacin treatment reflects underlying diminished renal function.