Hepatocyte polyploidization and its association with pathophysiological processes.
Hepatocyte polyploidization and its association with pathophysiological processes.
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肝细胞多倍化及其与病理生理过程的关系
DOI：
10.1038/cddis.2017.167
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发表时间：
2017-05-18
影响因子：
9
通讯作者：
Hu YP
中科院分区：
文献类型：
--
作者：
Wang MJ;Chen F;Lau JTY;Hu YP
哺乳动物肝脏的一个典型细胞特征是肝细胞逐渐多倍化，单个细胞获得两组以上的染色体。多倍化是在出生后发育过程中逐渐发生的细胞质分裂失败的结果。随着衰老过程或细胞应激，如手术切除、毒性刺激、代谢过载或氧化损伤，多倍体的比例也会增加，小鼠有90%的肝细胞参与，人类有40%。肝细胞多倍化通常被认为是终末分化和细胞衰老的指标，并与胰岛素和p53/p21信号通路的功能障碍有关。有趣的是，将衰老的肝细胞连续移植到幼年小鼠的肝脏中，可以逆转老年小鼠肝脏中肝细胞多倍化的高发生率。在此，我们对肝细胞多倍化在出生后生长、衰老和肝脏疾病中的作用机制进行综述。在考虑肝脏老化和肝脏疾病的新方法的背景下，多倍体在衰老逆转中的生物学意义被考虑。
A characteristic cellular feature of the mammalian liver is the progressive polyploidization of the hepatocytes, where individual cells acquire more than two sets of chromosomes. Polyploidization results from cytokinesis failure that takes place progressively during the course of postnatal development. The proportion of polyploidy also increases with the aging process or with cellular stress such as surgical resection, toxic stimulation, metabolic overload, or oxidative damage, to involve as much as 90% of the hepatocytes in mice and 40% in humans. Hepatocyte polyploidization is generally considered an indicator of terminal differentiation and cellular senescence, and related to the dysfunction of insulin and p53/p21 signaling pathways. Interestingly, the high prevalence of hepatocyte polyploidization in the aged mouse liver can be reversed when the senescent hepatocytes are serially transplanted into young mouse livers. Here we review the current knowledge on the mechanism of hepatocytes polyploidization during postnatal growth, aging, and liver diseases. The biologic significance of polyploidization in senescent reversal, within the context of new ways to think of liver aging and liver diseases is considered.
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DOI：
10.1002/hep.28573
发表时间：
2016-08
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Hsu SH;Delgado ER;Otero PA;Teng KY;Kutay H;Meehan KM;Moroney JB;Monga JK;Hand NJ;Friedman JR;Ghoshal K;Duncan AW
通讯作者：
Duncan AW
法尼醇X受体上调microRNA-122抑制肝细胞癌细胞的生长
影响因子：
37.3
作者：
He J;Zhao K;Zheng L;Xu Z;Gong W;Chen S;Shen X;Huang G;Gao M;Zeng Y;Zhang Y;He F
通讯作者：
He F
影响因子：
13.5
作者：
Chipchase, MD;O'Neill, M;Melton, DW
通讯作者：
Melton, DW
影响因子：
29.4
作者：
Duncan AW;Hanlon Newell AE;Smith L;Wilson EM;Olson SB;Thayer MJ;Strom SC;Grompe M
通讯作者：
Grompe M
DOI：
10.1073/pnas.1115201109
发表时间：
2012-03-06
影响因子：
11.1
作者：
Diril, M. Kasim;Ratnacaram, Chandrahas Koumar;Kaldis, Philipp
通讯作者：
Kaldis, Philipp