Zygosity diagnosis of twins by questionnaire for twins' mothers.
Zygosity diagnosis of twins by questionnaire for twins' mothers.
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通过对双胞胎母亲的问卷调查来诊断双胞胎的接合性。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
A. Asaka
中科院分区：
文献类型：
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作者：
S. Ooki;K. Yamada;A. Asaka
研究对象为日本东京大学附属高中74对双胞胎、61对mz和13对同性dz。他们的母亲也参与其中。这对双胞胎的合子性之前是通过许多遗传标记确定的。本研究旨在通过对双胞胎母亲发放问卷来阐明合子性诊断的有效性。问卷包括三个问题，涉及一岁时双胞胎的相似程度；他们是否被弄糊涂了，如果是，被谁弄糊涂了。与之前Ooki等人对双胞胎本身的报告相比，这一结果略有修改。根据双胞胎的相似程度，得分是这样的：问题(1)和(2)的答案从1分到3分，问题(3)的答案从1分到4分。计算积分的总和，然后从3到10不等。合子性由这些点的和决定。如果总和是3-6，双胞胎被认为是MZ，如果总和是7-10 DZ。结果表明，应用该切点，90%以上的双胞胎被正确识别为MZ或DZ，这一结果与使用判别函数分析的结果一致。此外，母亲们的回答的准确性与双胞胎自己的问卷调查结果几乎相同。因此，结论是，双胞胎母亲提供的信息和双胞胎自己提供的信息一样正确。这个问卷简单，实用，特别有用，当双胞胎还太小，不能亲自参与。
Subjects were 74 twin pairs, 61 MZs and 13 same-sexed DZs who entered the High School affiliated with Tokyo University, Japan. Their mothers also participated. The twins' zygosity was previously identified by many genetic markers. This study aimed at clarifying the effectiveness of zygosity diagnosis by questionnaires distributed to twins' mothers. The questionnaire consisted of three questions concerning the degree of similarity of twins at one year of age; whether they were confused, and if so, by whom. It was slightly modified from that reported earlier by Ooki et al [11] for twins themselves. According to the degree of similarity of the twins, points were allotted thus: from 1 to 3 points for answers to questions (1) and (2) and from 1 to 4 points for answers to questions (3). The sum of the points was calculated, then ranged from 3 to 10. Zygosity was determined by the sum of these points. If the sum was 3-6, the twin pairs were considered MZ and if the sum was 7-10 DZ. It was revealed that more than 90% of twins were identified correctly as MZ or DZ by applying this cutting point and this result was in accordance with that obtained by use of discriminant function analysis. Moreover, the accuracy of the mothers' responses was nearly the same as that obtained by the questionnaire for twins themselves. It was concluded, therefore, that the information from twins' mothers is as correct as that from twins themselves. This questionnaire is simple, practical and especially useful when twins are still too young to participate personally.