The non-human primate experimental glaucoma model
The non-human primate experimental glaucoma model
复制标题
DOI：
10.1016/j.exer.2015.06.005
复制
发表时间：
2015-12-01
影响因子：
3.4
通讯作者：
Burgoyne, Claude F.
中科院分区：
文献类型：
--
作者：
Burgoyne, Claude F.
本报告的目的是通过专门介绍其历史、方法、重要发现、替代视神经病变模型和未来方向的章节，总结非人灵长类动物（NHP）实验性青光眼（EG）模型的当前优势和劣势。NHP EG已被广泛用于研究人类青光眼，部分原因是NHP视神经乳头（ONH）与人类ONH具有密切的解剖学联系，并且因为它提供了系统研究慢性眼内压（LOP）升高（即从高眼压转化为青光眼损伤）的最早视觉系统反应的唯一方法。然而，NHP对于需要大量动物的研究是不切实际的，仅很少证明自发性青光眼，目前不能提供正常IOP水平下的神经病变模型，并且不能容易地进行遗传操作，除非通过组织特异性病毒载体。本总结的目的是指导NHP EG和非NHP EG研究者了解该模型中以前、当前和未来的临床相关知识。(C)2015爱思唯尔有限公司版权所有。
The purpose of this report is to summarize the current strengths and weaknesses of the non-human primate (NHP) experimental glaucoma (EG) model through sections devoted to its history, methods, important findings, alternative optic neuropathy models and future directions. NHP EG has become well established for studying human glaucoma in part because the NHP optic nerve head (ONH) shares a close anatomic association with the human ONH and because it provides the only means of systematically studying the very earliest visual system responses to chronic intraocular pressure (LOP) elevation, i.e. the conversion from ocular hypertension to glaucomatous damage. However, NHPs are impractical for studies that require large animal numbers, demonstrate spontaneous glaucoma only rarely, do not currently provide a model of the neuropathy at normal levels of IOP, and cannot easily be genetically manipulated, except through tissue-specific, viral vectors. The goal of this summary is to direct NHP EG and non-NHP EG investigators to the previous, current and future accomplishment of clinically relevant knowledge in this model. (C) 2015 Elsevier Ltd. All rights reserved.