Genetics of common forms of heart failure: challenges and potential solutions.
Genetics of common forms of heart failure: challenges and potential solutions.
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DOI：
10.1097/hco.0000000000000160
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发表时间：
2015-05
影响因子：
2.3
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Rau CD;Lusis AJ;Wang Y
与许多其他人类疾病相比，使用全基因组关联研究（GWAS）来识别心力衰竭（HF）基因的成功有限。我们将讨论潜在的挑战以及潜在的新方法来了解常见形式的HF的遗传学。最近的研究使用中间表型，更详细和定量分层的HF症状，创始人人口和新的动物模型已经开始允许研究人员取得进展，解释遗传学基础HF使用GWAS技术。通过扩大HF的分析，以改善临床特征，额外的HF分类和创新的模型系统，人类HF GWAS的棘手性应得到显着改善。
In contrast to many other human diseases, the use of genome-wide association studies (GWAS) to identify genes for heart failure (HF) has had limited success. We will discuss the underlying challenges as well as potential new approaches to understanding the genetics of common forms of HF. Recent research using intermediate phenotypes, more detailed and quantitative stratification of HF symptoms, founder populations and novel animal models has begun to allow researchers to make headway toward explaining the genetics underlying HF using GWAS techniques. By expanding analyses of HF to improved clinical traits, additional HF classifications and innovative model systems, the intractability of human HF GWAS should be ameliorated significantly.